rs1281036710
This variant is located in the RAD51D gene.
▶ClinVar annotation
Breast-ovarian cancer, familial, susceptibility to, 4; Hereditary cancer-predisposing syndrome
View on ClinVar →About RAD51D
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]
View all RAD51D variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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