RANBP10
RAN binding protein 10
Summary
RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Known Variants44 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1272134592 | 16:67,760,458 | G/A | — | uncertain significance |
| rs2543731065 | 16:67,761,316 | G/A | — | uncertain significance |
| rs142329294 | 16:67,761,689 | A/G | — | uncertain significance |
| rs756537213 | 16:67,761,695 | G/A | — | uncertain significance |
| rs775066644 | 16:67,761,770 | C/T | — | uncertain significance |
| rs374813468 | 16:67,761,781 | C/T | — | uncertain significance |
| rs142945039 | 16:67,762,414 | G/A | — | likely benign |
| rs756625027 | 16:67,763,231 | T/A | — | uncertain significance |
| rs2543742467 | 16:67,763,268 | G/T | — | uncertain significance |
| rs138394220 | 16:67,763,296 | C/G | — | likely benign |
| rs537689953 | 16:67,763,355 | C/T | — | uncertain significance |
| rs142221372 | 16:67,763,622 | G/A | — | uncertain significance |
| rs2053686967 | 16:67,763,658 | A/G | — | uncertain significance |
| rs751756862 | 16:67,763,669 | C/T | — | uncertain significance |
| rs757400628 | 16:67,763,672 | G/A | — | uncertain significance |
| rs745940697 | 16:67,763,681 | C/T | — | uncertain significance |
| rs540927913 | 16:67,763,684 | C/T | — | uncertain significance |
| rs61743481 | 16:67,763,698 | C/T | — | benign |
| rs1041928120 | 16:67,763,699 | G/A | — | uncertain significance |
| rs563799616 | 16:67,763,892 | C/T | — | uncertain significance |
| rs368209350 | 16:67,763,923 | G/A | — | uncertain significance |
| rs142473350 | 16:67,765,396 | C/A | — | uncertain significance |
| rs542995855 | 16:67,765,416 | G/C | — | uncertain significance |
| rs763086072 | 16:67,765,468 | C/T | — | uncertain significance |
| rs368732137 | 16:67,768,792 | G/A | — | uncertain significance |
| rs138529417 | 16:67,768,824 | T/C | — | uncertain significance |
| rs200891641 | 16:67,768,861 | T/C | — | uncertain significance |
| rs142204985 | 16:67,768,878 | T/C | — | uncertain significance |
| rs781681315 | 16:67,768,944 | G/A | — | uncertain significance |
| rs2543797003 | 16:67,778,212 | T/C | — | uncertain significance |
| rs150902552 | 16:67,778,237 | G/A | — | likely benign |
| rs2543797535 | 16:67,778,316 | T/A | — | uncertain significance |
| rs184527591 | 16:67,785,844 | A/C | intron variant | — |
| rs577309566 | 16:67,805,954 | T/C | — | uncertain significance |
| rs73591976 | 16:67,811,590 | C/A | intron variant | — |
| rs13336189 | 16:67,814,152 | C/A | intron variant | — |
| rs546473619 | 16:67,814,454 | C/T | — | — |
| rs150850722 | 16:67,829,537 | G/A | intron variant | — |
| rs779635531 | 16:67,840,214 | G/A | — | uncertain significance |
| rs139087878 | 16:67,840,266 | G/A | — | benign |
| rs375154077 | 16:67,840,357 | G/C | — | uncertain significance |
| rs766121018 | 16:67,840,391 | C/T | — | uncertain significance |
| rs765025030 | 16:67,840,417 | G/A | — | uncertain significance |
| rs746283429 | 16:67,840,426 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.