RASD1

ras related dexamethasone induced 1

Summary

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

Known Variants17 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs765040724	17:17,398,479	C/T	—	uncertain significance
rs2508394463	17:17,398,530	C/A	—	uncertain significance
rs774190385	17:17,398,546	C/T	—	uncertain significance
rs900096529	17:17,398,579	C/T	—	uncertain significance
rs372935650	17:17,398,745	C/G	—	uncertain significance
rs776140093	17:17,398,761	T/G	—	uncertain significance
rs1905396837	17:17,398,810	C/G	—	uncertain significance
rs1399188920	17:17,399,294	G/A	—	uncertain significance
rs2508397358	17:17,399,299	G/C	—	uncertain significance
rs2508397365	17:17,399,300	A/G	—	uncertain significance
rs148547257	17:17,399,327	T/C	—	uncertain significance
rs141915492	17:17,399,354	G/T	—	uncertain significance
rs2508397833	17:17,399,399	A/G	—	uncertain significance
rs1905428787	17:17,399,401	G/A	—	uncertain significance
rs2508397871	17:17,399,411	T/C	—	uncertain significance
rs2508397981	17:17,399,429	T/G	—	uncertain significance
rs2232831	17:17,400,049	A/T	regulatory region variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.