RFWD3

ring finger and WD repeat domain 3

Summary

Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Located in nucleoplasm and site of double-strand break. Implicated in Fanconi anemia complementation group W. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants428 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs139672835	16:74,657,829	C/T	—	likely benign
rs2543906153	16:74,657,832	C/T	—	uncertain significance
rs144438494	16:74,657,838	A/G	—	likely benign
rs775345045	16:74,657,839	T/A	—	uncertain significance
rs1958842201	16:74,657,844	G/A	—	likely benign
rs146574678	16:74,657,852	T/C	—	likely benign
rs756332506	16:74,657,865	G/T	—	likely benign
rs748988162	16:74,657,870	C/T	—	uncertain significance
rs754138211	16:74,657,875	T/C	—	uncertain significance
rs376027907	16:74,657,884	C/T	—	uncertain significance
rs150221303	16:74,657,885	G/A	—	uncertain significance
rs2543906795	16:74,657,890	A/G	—	uncertain significance
rs2543906903	16:74,657,896	A/G	—	uncertain significance
rs374299152	16:74,657,904	G/A	—	likely benign
rs747371853	16:74,657,906	T/C	—	uncertain significance
rs1462656314	16:74,657,907	G/A	—	likely benign
rs149759685	16:74,657,913	C/T	—	benign
rs775043994	16:74,657,924	C/T	—	conflicting classifications of pathogenicity
rs145714627	16:74,657,925	G/A	—	likely benign
rs763982760	16:74,657,928	C/G	—	uncertain significance
rs190386378	16:74,657,946	C/T	—	likely benign
rs1958846622	16:74,657,947	G/C	—	uncertain significance
rs765394837	16:74,657,956	G/C	—	uncertain significance
rs756889031	16:74,657,959	G/C	—	uncertain significance
rs202136713	16:74,657,972	A/G	—	likely benign
rs2543907955	16:74,657,974	A/G	—	likely benign
rs201236333	16:74,657,975	G/C	—	likely benign
rs1045215295	16:74,657,982	A/T	—	likely benign
rs745511636	16:74,657,983	G/C	—	likely benign
rs201384422	16:74,657,988	G/C	—	benign
rs1567564587	16:74,660,227	A/C	—	likely benign
rs767986935	16:74,660,232	C/G	—	likely benign
rs778553579	16:74,660,252	T/G	—	uncertain significance
rs2543921178	16:74,660,255	C/G	—	uncertain significance
rs149104426	16:74,660,264	C/A	—	uncertain significance
rs760505640	16:74,660,270	T/C	—	uncertain significance
rs1958931902	16:74,660,276	C/T	—	uncertain significance
rs544861544	16:74,660,282	T/C	—	uncertain significance
rs763237873	16:74,660,284	T/G	—	uncertain significance
rs762199789	16:74,660,293	T/C	—	uncertain significance
rs767977113	16:74,660,312	T/C	—	uncertain significance
rs2543921901	16:74,660,322	G/C	—	likely benign
rs756415611	16:74,660,328	T/C	—	likely benign
rs200603961	16:74,660,334	G/A	—	likely benign
rs2543922035	16:74,660,337	A/G	—	likely benign
rs1238813457	16:74,660,339	T/C	—	uncertain significance
rs778265025	16:74,660,341	G/C	—	uncertain significance
rs777802762	16:74,660,352	A/G	—	likely benign
rs746955316	16:74,660,359	T/C	—	uncertain significance
rs776553550	16:74,660,363	C/T	—	uncertain significance
rs749453678	16:74,660,367	C/G	—	uncertain significance
rs2543922603	16:74,660,377	C/A	—	uncertain significance
rs993787960	16:74,660,380	A/T	—	uncertain significance
rs768967844	16:74,660,381	T/C	—	conflicting classifications of pathogenicity
rs143173893	16:74,660,382	T/C	—	benign
rs767600574	16:74,660,394	G/A	—	likely benign
rs2543922817	16:74,660,397	A/G	—	likely benign
rs1958937573	16:74,660,398	T/C	—	uncertain significance
rs141321984	16:74,660,404	C/T	—	uncertain significance
rs1459142609	16:74,660,405	G/A	—	uncertain significance
rs754278440	16:74,660,409	G/T	—	likely benign
rs1175256500	16:74,660,426	C/T	—	uncertain significance
rs774649273	16:74,660,428	C/T	—	uncertain significance
rs746935093	16:74,660,432	G/A	—	uncertain significance
rs570050535	16:74,660,439	G/C	—	likely benign
rs757318624	16:74,660,450	T/C	—	uncertain significance
rs1958941385	16:74,660,455	A/G	—	uncertain significance
rs373621395	16:74,660,459	G/A	—	likely benign
rs745712842	16:74,660,466	A/G	—	likely benign
rs752326359	16:74,662,337	C/T	—	likely benign
rs758187731	16:74,662,341	A/T	—	likely benign
rs1294963127	16:74,662,351	A/G	—	uncertain significance
rs1322337193	16:74,662,354	C/G	—	uncertain significance
rs201418176	16:74,662,357	G/A	—	likely benign
rs2543933751	16:74,662,360	G/A	—	likely benign
rs137961728	16:74,662,363	C/G	—	benign
rs2543933820	16:74,662,370	C/T	—	uncertain significance
rs1184333222	16:74,662,376	C/T	—	uncertain significance
rs755874703	16:74,662,377	G/T	—	likely benign
rs2543934025	16:74,662,395	G/C	—	uncertain significance
rs2543934068	16:74,662,398	A/G	—	uncertain significance
rs1555524842	16:74,662,403	A/T	—	pathogenic
rs1597408998	16:74,662,416	G/A	—	uncertain significance
rs2543934338	16:74,662,420	C/T	—	likely benign
rs779783050	16:74,662,422	A/C	—	uncertain significance
rs2543934469	16:74,662,431	C/G	—	uncertain significance
rs1349428055	16:74,662,434	G/A	—	uncertain significance
rs777799464	16:74,662,441	A/G	—	likely benign
rs993223067	16:74,662,451	T/C	—	uncertain significance
rs2543934768	16:74,662,453	C/A	—	uncertain significance
rs2543934785	16:74,662,456	T/C	—	likely benign
rs770936794	16:74,662,464	C/G	—	uncertain significance
rs141685768	16:74,662,479	C/T	—	conflicting classifications of pathogenicity
rs2543935107	16:74,662,485	A/G	—	likely benign
rs556158961	16:74,662,486	G/C	—	likely benign
rs763875920	16:74,662,487	G/C	—	uncertain significance
rs2543935334	16:74,662,503	C/T	—	uncertain significance
rs1444577160	16:74,662,508	T/C	—	uncertain significance
rs2543935521	16:74,662,518	C/G	—	uncertain significance
rs1359998441	16:74,662,528	A/C	—	likely benign

Showing 100 of 428 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.