RGS6

regulator of G protein signaling 6

Summary

This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]

Known Variants129 total

rsidPosition (GRCh37)AllelesClassClinVar
rs219087314:72,424,905T/Cintron variant—
rs206785414:72,425,819G/Aintron variant—
rs14093031814:72,431,210T/C—likely benign
rs7788450214:72,431,455C/T—benign
rs2867861214:72,431,464A/G—benign
rs20019398214:72,431,555C/T—uncertain significance
rs77946351114:72,431,581G/A—uncertain significance
rs6175565114:72,431,599T/C—benign
rs490296014:72,432,149G/Aintron variant—
rs1289754214:72,449,591A/Gintron variant—
rs1162349214:72,462,557A/Gupstream gene variant—
rs489941214:72,464,262T/Cintron variant—
rs205201514:72,487,053C/G——
rs69936314:72,692,493G/T——
rs84735414:72,781,929T/Cintron variant—
rs268173514:72,812,525A/Gintron variant—
rs268174414:72,815,284C/Aintron variant—
rs14561451614:72,818,615G/T—likely benign
rs6174950414:72,818,811C/T—likely benign
rs14258537814:72,818,812A/C—uncertain significance
rs76876590414:72,818,836A/G—uncertain significance
rs127313146614:72,818,852C/T—uncertain significance
rs19966918714:72,818,865C/G—likely benign
rs76745407214:72,818,890A/G—uncertain significance
rs254449152014:72,818,891G/A—uncertain significance
rs11269604114:72,818,909C/T—likely benign
rs13942133314:72,818,968C/T—likely benign
rs223921914:72,852,820A/Gintron variant—
rs715930014:72,883,874G/Aregulatory region variant—
rs7329495514:72,885,562C/A——
rs52887537014:72,921,229G/A—likely benign
rs205696325214:72,921,275T/C—uncertain significance
rs99938308314:72,921,292T/C—uncertain significance
rs230214414:72,921,417C/G—benign
rs14083059114:72,924,689A/G—likely benign
rs1711602314:72,924,715C/T—likely benign
rs1711602914:72,924,765T/C—likely benign
rs159780494014:72,924,992C/T—likely benign
rs89730306114:72,924,993T/C—likely benign
rs36764381314:72,925,008G/T—uncertain significance
rs223818614:72,925,171G/C—benign
rs223818414:72,926,086T/A—benign
rs11325523414:72,926,141C/G—benign
rs223818314:72,926,165G/A—benign
rs11587421214:72,926,244G/A—likely benign
rs14094192514:72,926,499G/C—likely benign
rs19288213014:72,932,302A/T—benign
rs5585491714:72,932,306A/G—benign
rs20098060014:72,932,310T/A—benign
rs14395209614:72,932,316G/A—benign
rs7894236014:72,932,389G/T—benign
rs11168121314:72,932,515G/C—likely benign
rs209589502714:72,932,516G/A—uncertain significance
rs7503648014:72,932,563A/G—benign
rs2842892614:72,932,809A/G—benign
rs13977212914:72,936,461T/G—likely benign
rs91447103914:72,936,710A/C—likely benign
rs77681919014:72,936,787G/C—uncertain significance
rs2870892714:72,936,808G/A—likely benign
rs14258462714:72,936,938C/T—likely benign
rs801203714:72,936,954T/C—benign
rs1013130014:72,939,495C/Aintron variantbenign
rs76910476414:72,939,624G/C—uncertain significance
rs1013149714:72,939,735C/T—benign
rs18874487314:72,939,922C/T—likely benign
rs800806714:72,941,207G/A—benign
rs14342003714:72,941,379G/A—uncertain significance
rs56266778014:72,941,411C/T—uncertain significance
rs207495314:72,943,176C/T—benign
rs14192282114:72,943,453G/A—uncertain significance
rs14631367514:72,943,462G/A—uncertain significance
rs4130435914:72,943,527A/G—likely benign
rs11586147814:72,943,751C/T—likely benign
rs1205043014:72,943,752C/T—benign
rs11550656314:72,944,693C/T—likely benign
rs223927714:72,944,943G/T—benign
rs230214314:72,945,012C/T—benign
rs74589480414:72,945,020G/A—uncertain significance
rs11415698814:72,945,048C/T—benign
rs1711646414:72,961,598T/C—benign
rs74667093214:72,961,875G/A—likely benign
rs119170120914:72,961,890A/C—uncertain significance
rs74559327814:72,961,937G/A—uncertain significance
rs13984036414:72,961,938C/T—likely benign
rs20109307514:72,961,939G/A—uncertain significance
rs11579626314:72,962,155G/A—likely benign
rs228607214:72,976,585T/C—benign
rs1718071214:72,976,615T/C—benign
rs7738780814:72,976,630G/A—benign
rs2853367214:72,976,799G/A—likely benign
rs11501309514:72,976,852C/T—benign
rs122294710514:72,976,884G/A—uncertain significance
rs14418463314:72,976,936G/A—uncertain significance
rs77121563014:72,976,951G/A—uncertain significance
rs55115207014:72,977,057C/G—benign
rs461778414:72,977,081A/C—benign
rs434615114:72,977,084A/G—benign
rs500827414:72,977,154C/T—benign
rs7272616714:72,977,189G/A—benign
rs1214747414:72,977,199A/G—benign

Showing 100 of 129 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.