RHOBTB2

Rho related BTB domain containing 2

Summary

The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Known Variants582 total

rsidPosition (GRCh37)AllelesClassClinVar
rs37393778:22,852,043T/C—benign
rs78418748:22,852,071C/T—likely benign
rs788868428:22,852,096A/G—benign
rs9750870608:22,852,098T/C—uncertain significance
rs13067437828:22,852,101A/C—likely benign
rs12305124408:22,852,110G/A—uncertain significance
rs1866958338:22,852,116G/A—conflicting classifications of pathogenicity
rs11823834228:22,852,117C/A—likely benign
rs7751905038:22,852,120C/T—likely benign
rs14460820288:22,852,121G/A—likely benign
rs14192258838:22,852,129C/T—likely benign
rs9669552108:22,852,134A/G—likely benign
rs1925412458:22,852,136A/G—likely benign
rs13540088668:22,852,138C/T—likely benign
rs24869396748:22,852,144A/G—likely benign
rs13555536168:22,852,150C/T—likely benign
rs10351642188:22,852,159A/G—likely benign
rs14268851868:22,852,163A/G—likely benign
rs13347669558:22,852,165T/C—likely benign
rs24869397918:22,852,167T/G—likely benign
rs24869397988:22,852,169T/C—likely benign
rs18105000608:22,852,171C/T—likely benign
rs1124006418:22,853,222C/G—benign
rs7506174538:22,853,392C/A—likely benign
rs5620083038:22,853,393G/A—likely benign
rs7751355448:22,857,191C/G—benign
rs5518716488:22,857,507T/G—benign
rs3748062188:22,861,918G/A—likely benign
rs578364928:22,861,927C/A—likely benign
rs24869926058:22,861,928T/C—likely benign
rs7797963248:22,861,942C/T—uncertain significance
rs7466812348:22,861,943G/A—benign
rs24869926838:22,861,948A/G—uncertain significance
rs7682394998:22,861,959C/T—likely benign
rs9275193838:22,861,960A/G—uncertain significance
rs7480957528:22,861,980C/T—likely benign
rs1446451868:22,861,981G/A—uncertain significance
rs7730511838:22,861,983A/G—likely benign
rs21288033098:22,861,994A/G—uncertain significance
rs9575808608:22,861,999G/A—uncertain significance
rs18108874698:22,862,003T/C—uncertain significance
rs7625857738:22,862,016C/T—likely benign
rs24869930688:22,862,018C/T—benign
rs3725201778:22,862,019C/T—likely benign
rs7745188718:22,862,020G/A—likely benign
rs24869931538:22,862,025T/C—likely benign
rs24869931748:22,862,027A/G—uncertain significance
rs617599108:22,862,037C/A—benign
rs24869932358:22,862,038A/G—uncertain significance
rs18108896548:22,862,047C/T—uncertain significance
rs9497453618:22,862,048G/A—likely benign
rs7675661368:22,862,049C/T—likely benign
rs13420731898:22,862,050G/T—likely pathogenic
rs18108906768:22,862,067C/A—likely benign
rs21288033548:22,862,070C/A—likely benign
rs7543847158:22,862,090C/T—likely benign
rs7710033428:22,862,091G/A—likely benign
rs24869936048:22,862,093A/C—uncertain significance
rs617327708:22,862,115C/T—benign
rs7693477088:22,862,121A/G—likely benign
rs7775113848:22,862,126G/A—likely benign
rs7766525738:22,862,127T/C—likely benign
rs7706845918:22,862,143A/C—uncertain significance
rs24725668:22,862,763T/C—benign
rs7524059678:22,862,866T/C—likely benign
rs3727338748:22,862,868T/C—likely benign
rs12170023308:22,862,871C/T—likely benign
rs5357875018:22,862,873C/T—likely benign
rs24869984818:22,862,874C/T—likely benign
rs1120939548:22,862,877A/G—benign
rs12674077368:22,862,879C/T—likely benign
rs9511258878:22,862,881C/G—likely benign
rs18109162928:22,862,894C/T—likely benign
rs24869985998:22,862,895G/T—uncertain significance
rs24869986488:22,862,899C/T—likely benign
rs12150594558:22,862,900C/T—uncertain significance
rs7755279958:22,862,901G/A—likely benign
rs7685859868:22,862,906G/A—benign
rs12945832188:22,862,908G/A—likely benign
rs21288037418:22,862,910T/C—uncertain significance
rs1932412138:22,862,917T/C—likely benign
rs3727215168:22,862,920C/T—likely benign
rs3677157148:22,862,923C/T—likely benign
rs15632905368:22,862,924G/A—benign
rs7659109308:22,862,926C/G—likely benign
rs12907232848:22,862,934G/A—uncertain significance
rs13570682808:22,862,940G/A—conflicting classifications of pathogenicity
rs24869989758:22,862,960C/T—likely pathogenic
rs24869990038:22,862,968C/G—uncertain significance
rs7633481218:22,862,969C/G—uncertain significance
rs24869990408:22,862,972C/T—likely pathogenic
rs13043981488:22,862,974C/T—likely benign
rs7667862978:22,862,977T/C—likely benign
rs24869990848:22,862,982A/G—uncertain significance
rs24869991078:22,862,985G/A—pathogenic
rs9211671808:22,862,989G/A—likely benign
rs21288037748:22,862,999C/T—likely benign
rs3715003978:22,863,000C/T—benign
rs24308118:22,863,004A/G—benign
rs7635029908:22,863,007C/T—likely benign

Showing 100 of 582 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.