RNF186
ring finger protein 186
Summary
Enables ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of with a positive effect on regulation of autophagosome assembly. Located in endoplasmic reticulum membrane. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1317209 | 1:20,140,036 | G/A | downstream gene variant | — |
| rs2044697898 | 1:20,140,916 | C/T | — | uncertain significance |
| rs2524253375 | 1:20,140,942 | T/C | — | uncertain significance |
| rs1038574792 | 1:20,140,951 | C/A | — | uncertain significance |
| rs375945232 | 1:20,140,987 | C/T | — | likely benign |
| rs199540262 | 1:20,140,988 | G/A | — | uncertain significance |
| rs1350245499 | 1:20,141,035 | G/A | — | uncertain significance |
| rs202025693 | 1:20,141,059 | C/T | — | uncertain significance |
| rs36095412 | 1:20,141,060 | G/A | stop gained | — |
| rs533469408 | 1:20,141,071 | G/A | — | uncertain significance |
| rs572971609 | 1:20,141,080 | A/T | — | uncertain significance |
| rs372463789 | 1:20,141,125 | G/A | — | likely benign |
| rs41264109 | 1:20,141,126 | C/T | — | uncertain significance |
| rs763892906 | 1:20,141,134 | C/T | — | uncertain significance |
| rs143610472 | 1:20,141,138 | G/A | — | uncertain significance |
| rs150096868 | 1:20,141,150 | G/T | — | uncertain significance |
| rs770331438 | 1:20,141,196 | G/T | — | uncertain significance |
| rs535476759 | 1:20,141,215 | G/A | — | uncertain significance |
| rs760509691 | 1:20,141,219 | G/A | — | uncertain significance |
| rs142776324 | 1:20,141,225 | C/T | — | uncertain significance |
| rs139260117 | 1:20,141,237 | G/T | — | uncertain significance |
| rs367913080 | 1:20,141,257 | C/T | — | uncertain significance |
| rs116045850 | 1:20,141,297 | G/A | — | uncertain significance |
| rs755435727 | 1:20,141,312 | G/A | — | uncertain significance |
| rs372014586 | 1:20,141,390 | G/A | — | uncertain significance |
| rs1401333777 | 1:20,141,400 | G/C | — | uncertain significance |
| rs368042107 | 1:20,141,443 | C/T | — | uncertain significance |
| rs754488757 | 1:20,141,497 | G/C | — | uncertain significance |
| rs775644469 | 1:20,141,555 | A/C | — | uncertain significance |
| rs147586351 | 1:20,141,556 | G/C | — | uncertain significance |
| rs1157836101 | 1:20,141,575 | A/G | — | likely benign |
| rs3806308 | 1:20,142,866 | C/T | regulatory region variant | — |
| rs3806306 | 1:20,143,100 | A/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.