ROCK2

Rho associated coiled-coil containing protein kinase 2

Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

Known Variants78 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs978906	2:11,323,276	T/A	—	—
rs6753921	2:11,326,755	G/C	—	—
rs1483703733	2:11,332,307	C/T	—	uncertain significance
rs201801097	2:11,332,422	T/G	—	uncertain significance
rs779803586	2:11,332,606	T/C	—	uncertain significance
rs2527740216	2:11,332,706	A/G	—	uncertain significance
rs552881592	2:11,332,757	A/C	—	uncertain significance
rs1558277937	2:11,332,802	G/A	—	uncertain significance
rs2271621	2:11,333,994	G/T	—	benign
rs55839233	2:11,334,384	T/G	—	benign
rs759845445	2:11,337,374	T/G	—	uncertain significance
rs1383664600	2:11,337,801	G/A	—	uncertain significance
rs780090672	2:11,338,664	C/T	—	uncertain significance
rs372763637	2:11,338,679	C/T	—	uncertain significance
rs752852649	2:11,341,108	G/A	—	uncertain significance
rs1558285391	2:11,341,115	C/G	—	not provided
rs2527779793	2:11,341,163	T/A	—	uncertain significance
rs2527779878	2:11,341,184	A/G	—	uncertain significance
rs200468857	2:11,341,517	C/G	—	uncertain significance
rs145334990	2:11,341,545	T/C	—	benign
rs2527785768	2:11,342,209	T/G	—	uncertain significance
rs2527785800	2:11,342,214	C/T	—	likely benign
rs369373069	2:11,342,255	G/C	—	likely benign
rs186901433	2:11,344,274	T/C	intron variant	—
rs55931955	2:11,347,941	T/G	—	benign
rs368029536	2:11,348,023	G/A	—	uncertain significance
rs201820613	2:11,348,524	C/G	—	uncertain significance
rs188469889	2:11,348,529	C/A	—	uncertain significance
rs371591492	2:11,351,809	T/C	—	uncertain significance
rs200234402	2:11,351,838	G/A	—	likely benign
rs1460310600	2:11,351,845	T/C	—	uncertain significance
rs869312716	2:11,351,870	G/A	—	uncertain significance
rs762297001	2:11,351,912	T/C	—	uncertain significance
rs10495582	2:11,354,308	G/C	intron variant	—
rs767495736	2:11,354,538	G/A	—	uncertain significance
rs200475392	2:11,354,539	C/T	—	uncertain significance
rs778490468	2:11,355,016	G/C	—	uncertain significance
rs1160193624	2:11,355,056	G/T	—	uncertain significance
rs35768389	2:11,355,100	T/A	—	benign
rs916700847	2:11,355,438	T/G	—	likely benign
rs1280448114	2:11,355,454	T/C	—	uncertain significance
rs2148066424	2:11,355,654	G/A	—	uncertain significance
rs753011445	2:11,355,692	T/C	—	uncertain significance
rs1013023821	2:11,356,319	G/A	—	uncertain significance
rs758533507	2:11,357,264	T/C	—	uncertain significance
rs377125275	2:11,358,573	C/A	—	likely benign
rs2527869471	2:11,359,094	C/T	—	uncertain significance
rs2527869994	2:11,359,116	A/C	—	uncertain significance
rs2230774	2:11,359,120	G/T	missense variant	benign
rs375372605	2:11,361,388	T/C	—	uncertain significance
rs2527880695	2:11,361,411	T/C	—	uncertain significance
rs201316858	2:11,364,488	T/C	—	uncertain significance
rs559020986	2:11,364,521	A/T	—	uncertain significance
rs10176416	2:11,366,800	G/A	intron variant	—
rs773789965	2:11,367,430	C/T	—	uncertain significance
rs1665180586	2:11,375,833	C/G	—	uncertain significance
rs1665183069	2:11,375,938	T/C	—	uncertain significance
rs1016039350	2:11,376,049	C/T	—	uncertain significance
rs376820323	2:11,389,806	T/C	—	uncertain significance
rs2230773	2:11,389,814	G/A	synonymous variant	benign
rs201939803	2:11,389,842	A/C	—	likely benign
rs1297052243	2:11,389,862	T/C	—	uncertain significance
rs774529136	2:11,389,902	T/G	—	uncertain significance
rs1191034888	2:11,389,921	G/A	—	uncertain significance
rs10178332	2:11,409,017	C/G	—	—
rs10929728	2:11,411,483	T/G	—	—
rs368014961	2:11,426,751	T/C	—	uncertain significance
rs199867337	2:11,484,142	T/C	—	likely benign
rs1036134868	2:11,484,154	G/A	—	uncertain significance
rs201281924	2:11,484,160	G/C	—	uncertain significance
rs745722011	2:11,484,186	C/A	—	uncertain significance
rs199520770	2:11,484,202	C/A	—	uncertain significance
rs368832806	2:11,484,212	C/A	—	likely benign
rs371946291	2:11,484,213	G/A	—	likely benign
rs2527354275	2:11,484,229	C/G	—	uncertain significance
rs867931783	2:11,484,246	G/A	—	uncertain significance
rs746788461	2:11,484,251	G/A	—	likely benign
rs56309145	2:11,485,139	G/C	regulatory region variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.