ROS1

ROS proto-oncogene 1, receptor tyrosine kinase

Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Known Variants180 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs766555708	6:117,609,669	C/T	—	uncertain significance
rs1442866318	6:117,609,678	C/T	—	uncertain significance
rs143434059	6:117,609,714	G/C	—	uncertain significance
rs35932630	6:117,609,716	T/C	—	benign
rs779731708	6:117,609,739	T/G	—	uncertain significance
rs768332561	6:117,609,747	C/T	—	uncertain significance
rs375010729	6:117,609,929	T/C	—	uncertain significance
rs2128521382	6:117,609,952	A/C	—	uncertain significance
rs1412107750	6:117,609,963	C/T	—	uncertain significance
rs483223	6:117,620,363	G/T	—	—
rs1275344272	6:117,622,176	C/T	—	uncertain significance
rs619203	6:117,622,184	G/C	missense variant	benign
rs529156	6:117,622,188	T/G	missense variant	benign
rs760646608	6:117,622,211	T/A	—	uncertain significance
rs75510639	6:117,622,231	G/T	—	likely benign
rs529038	6:117,622,233	C/T	missense variant	benign
rs145104466	6:117,622,256	C/A	—	uncertain significance
rs210966	6:117,624,598	C/G	regulatory region variant	—
rs663474	6:117,629,663	T/C	intron variant	—
rs2128546196	6:117,630,038	G/C	—	uncertain significance
rs145358991	6:117,631,291	A/G	—	likely benign
rs199882276	6:117,631,301	C/T	—	conflicting classifications of pathogenicity
rs150262256	6:117,631,362	C/A	—	uncertain significance
rs758255859	6:117,631,414	G/A	—	likely benign
rs1775437483	6:117,631,424	C/T	—	uncertain significance
rs201894511	6:117,632,256	C/T	—	uncertain significance
rs758446263	6:117,638,317	G/A	—	uncertain significance
rs557108710	6:117,638,342	G/T	—	uncertain significance
rs1484038087	6:117,638,344	C/T	—	uncertain significance
rs1057519788	6:117,638,347	C/T	missense variant	pathogenic
rs2128555797	6:117,638,424	T/C	—	uncertain significance
rs139620900	6:117,639,389	C/A	—	uncertain significance
rs760855335	6:117,641,060	C/T	—	uncertain significance
rs371159504	6:117,641,062	A/T	—	uncertain significance
rs1266834243	6:117,641,164	T/C	—	likely benign
rs150750988	6:117,641,458	A/C	—	benign
rs9489124	6:117,642,495	C/T	—	benign
rs144529412	6:117,642,531	T/C	—	likely benign
rs768363603	6:117,642,551	T/C	—	uncertain significance
rs575006	6:117,644,132	C/T	intron variant	—
rs76039658	6:117,650,483	C/T	—	benign
rs149390376	6:117,650,514	T/G	—	uncertain significance
rs762445305	6:117,650,523	A/G	—	uncertain significance
rs12664076	6:117,650,532	C/G	—	benign
rs2128593376	6:117,650,550	G/C	—	uncertain significance
rs2128593457	6:117,650,564	C/G	—	uncertain significance
rs1213350416	6:117,658,340	G/T	—	uncertain significance
rs771301135	6:117,658,356	G/C	—	uncertain significance
rs148667396	6:117,658,363	G/A	—	likely benign
rs143435239	6:117,658,368	T/G	—	uncertain significance
rs1436828538	6:117,658,400	C/T	—	uncertain significance
rs577629463	6:117,658,460	T/A	—	uncertain significance
rs1777556873	6:117,658,476	T/C	—	uncertain significance
rs776465526	6:117,658,478	A/G	—	uncertain significance
rs1400675993	6:117,658,482	G/C	—	uncertain significance
rs150943500	6:117,658,489	C/T	—	likely benign
rs765137339	6:117,658,492	A/T	—	uncertain significance
rs2128617513	6:117,658,549	T/G	—	uncertain significance
rs1281997419	6:117,662,329	T/C	—	uncertain significance
rs780702994	6:117,662,391	A/G	—	likely benign
rs184429367	6:117,662,402	G/T	—	benign
rs201532881	6:117,662,428	G/A	—	uncertain significance
rs768081803	6:117,662,460	G/C	—	uncertain significance
rs767933411	6:117,662,738	A/G	—	uncertain significance
rs779188243	6:117,663,568	T/G	—	uncertain significance
rs2534095537	6:117,663,626	A/G	—	uncertain significance
rs750621559	6:117,663,646	T/C	—	uncertain significance
rs138573193	6:117,663,656	A/G	—	uncertain significance
rs986408985	6:117,663,661	G/A	—	uncertain significance
rs112739824	6:117,663,667	G/T	—	uncertain significance
rs35841892	6:117,665,231	T/C	—	benign
rs141056178	6:117,665,328	T/G	—	benign
rs765083865	6:117,665,371	G/A	—	uncertain significance
rs147732228	6:117,665,425	T/C	—	uncertain significance
rs1779006110	6:117,674,196	A/C	—	uncertain significance
rs1779012416	6:117,674,263	C/A	—	uncertain significance
rs750846787	6:117,674,302	T/A	—	uncertain significance
rs181940078	6:117,677,789	T/C	—	likely benign
rs1582721701	6:117,677,883	T/C	—	likely benign
rs368099011	6:117,677,902	G/T	—	uncertain significance
rs145742603	6:117,677,927	A/G	—	benign
rs2128644222	6:117,677,990	G/T	—	uncertain significance
rs148950746	6:117,678,024	A/G	—	likely benign
rs764738348	6:117,678,036	C/T	—	uncertain significance
rs1562309446	6:117,678,047	C/A	—	uncertain significance
rs199725375	6:117,678,077	G/A	—	uncertain significance
rs923546663	6:117,679,060	A/G	—	uncertain significance
rs1161261865	6:117,679,126	T/C	—	uncertain significance
rs751581315	6:117,679,131	T/G	—	likely benign
rs2534265728	6:117,680,989	T/C	—	uncertain significance
rs35302901	6:117,680,994	A/T	—	likely pathogenic
rs567175783	6:117,681,036	A/G	—	uncertain significance
rs749977900	6:117,681,061	C/T	—	likely benign
rs56076986	6:117,681,062	G/A	—	likely benign
rs1228020371	6:117,681,074	T/A	—	uncertain significance
rs35613256	6:117,681,089	C/T	—	benign
rs755947749	6:117,681,463	G/A	—	benign
rs151330473	6:117,681,547	C/T	—	pathogenic
rs140639104	6:117,681,560	G/T	—	benign
rs371737902	6:117,683,743	A/G	—	uncertain significance

Showing 100 of 180 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.