rs1057519788

This is a variant in the ROS1 gene that changes a glycine to an arginine.

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ClinVar annotation

Pathogenic

1 submitter

Lung adenocarcinoma

About ROS1

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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