RPL15

ribosomal protein L15

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

Known Variants118 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs116177228	3:23,959,223	A/C	—	likely benign
rs56222205	3:23,959,257	T/C	—	likely benign
rs567287618	3:23,959,350	G/C	—	uncertain significance
rs774562896	3:23,959,368	C/T	—	likely benign
rs2471214132	3:23,959,373	A/C	—	uncertain significance
rs2471214224	3:23,959,379	T/C	—	pathogenic
rs935839158	3:23,959,395	G/A	—	likely benign
rs746016083	3:23,959,397	C/G	—	uncertain significance
rs2471214406	3:23,959,398	T/A	—	likely benign
rs772286584	3:23,959,405	A/G	—	uncertain significance
rs35629664	3:23,959,425	C/G	—	likely benign
rs2471214687	3:23,959,435	C/T	—	pathogenic
rs2125251133	3:23,959,437	G/T	—	uncertain significance
rs766367909	3:23,959,451	C/T	—	uncertain significance
rs1199176508	3:23,959,453	G/A	—	uncertain significance
rs2471214973	3:23,959,468	C/T	—	uncertain significance
rs751502211	3:23,959,470	C/T	—	likely benign
rs1208689790	3:23,959,472	G/T	—	uncertain significance
rs2471215084	3:23,959,474	C/T	—	uncertain significance
rs766954372	3:23,959,478	C/T	—	uncertain significance
rs778175191	3:23,959,488	T/G	—	uncertain significance
rs1368142965	3:23,959,495	C/T	—	uncertain significance
rs2471215315	3:23,959,496	G/A	—	uncertain significance
rs2471215376	3:23,959,501	C/G	—	uncertain significance
rs749731223	3:23,959,506	C/T	—	likely benign
rs1292991492	3:23,959,515	C/T	—	likely benign
rs2125251374	3:23,959,516	A/G	—	uncertain significance
rs2125251388	3:23,959,518	G/A	—	likely benign
rs1388735901	3:23,959,521	A/G	—	uncertain significance
rs369956511	3:23,959,527	G/A	—	conflicting classifications of pathogenicity
rs2471215780	3:23,959,529	G/A	—	likely benign
rs747226050	3:23,959,537	G/A	—	likely benign
rs113395170	3:23,959,881	A/G	—	likely benign
rs36038704	3:23,959,913	G/A	—	benign
rs369227929	3:23,959,921	T/C	—	likely benign
rs560692338	3:23,959,927	G/A	—	benign
rs192491916	3:23,959,935	C/T	—	benign
rs771958480	3:23,959,936	G/A	—	uncertain significance
rs754454565	3:23,959,938	T/C	—	likely benign
rs760039869	3:23,959,954	G/A	—	uncertain significance
rs2125253315	3:23,959,969	C/T	—	pathogenic
rs2471220957	3:23,959,970	G/A	—	uncertain significance
rs2471220996	3:23,959,973	A/G	—	uncertain significance
rs2471221010	3:23,959,975	C/T	—	uncertain significance
rs149401472	3:23,959,998	T/A	—	likely benign
rs35608037	3:23,960,001	C/T	—	benign
rs1176899362	3:23,960,002	G/A	—	uncertain significance
rs2471221298	3:23,960,015	A/G	—	uncertain significance
rs146413350	3:23,960,032	C/A	—	uncertain significance
rs143514719	3:23,960,040	T/C	—	benign
rs770047384	3:23,960,052	T/G	—	likely benign
rs2471221537	3:23,960,055	G/T	—	uncertain significance
rs2471221620	3:23,960,062	G/C	—	uncertain significance
rs1197292236	3:23,960,079	T/G	—	likely benign
rs35054246	3:23,960,080	G/C	—	benign
rs752373728	3:23,960,082	G/C	—	likely benign
rs775525444	3:23,960,669	C/G	—	likely benign
rs368646822	3:23,960,680	A/G	—	likely benign
rs1358191044	3:23,960,683	C/G	—	likely benign
rs886041445	3:23,960,685	A/G	—	pathogenic
rs1704930969	3:23,960,691	G/T	—	likely pathogenic
rs2125255748	3:23,960,697	G/C	—	uncertain significance
rs1398566766	3:23,960,699	C/A	—	uncertain significance
rs749541129	3:23,960,700	G/A	—	uncertain significance
rs998038229	3:23,960,701	C/T	—	likely benign
rs2125255778	3:23,960,707	T/C	—	likely benign
rs2471230363	3:23,960,714	C/T	—	likely benign
rs558281601	3:23,960,716	G/C	—	benign
rs768764156	3:23,960,718	G/C	—	uncertain significance
rs2125255813	3:23,960,726	A/G	—	uncertain significance
rs2471230549	3:23,960,734	C/T	—	likely benign
rs747729430	3:23,960,740	T/C	—	likely benign
rs2471230576	3:23,960,741	G/T	—	uncertain significance
rs151218632	3:23,960,758	C/T	—	likely benign
rs774230761	3:23,960,760	A/G	—	uncertain significance
rs2471230768	3:23,960,763	T/A	—	uncertain significance
rs1184852875	3:23,960,773	T/C	—	likely benign
rs766621970	3:23,960,779	C/T	—	likely benign
rs1158480748	3:23,960,782	T/G	—	uncertain significance
rs1301264124	3:23,960,804	A/G	—	uncertain significance
rs1340337879	3:23,960,813	C/G	—	uncertain significance
rs1575121446	3:23,960,815	T/C	—	likely benign
rs534301057	3:23,960,816	G/A	—	conflicting classifications of pathogenicity
rs768075641	3:23,960,818	C/T	—	likely benign
rs1352583583	3:23,960,820	C/G	—	uncertain significance
rs1198474970	3:23,960,823	A/G	—	uncertain significance
rs756131448	3:23,960,824	G/A	—	likely benign
rs370700905	3:23,960,835	A/C	—	pathogenic
rs753971737	3:23,960,837	C/G	—	uncertain significance
rs373573769	3:23,960,854	G/A	—	benign
rs1575121565	3:23,960,863	T/A	—	likely benign
rs181790084	3:23,960,872	A/T	—	likely benign
rs748116544	3:23,960,882	C/G	—	uncertain significance
rs769387719	3:23,960,883	G/T	—	uncertain significance
rs2125256159	3:23,960,891	C/T	—	uncertain significance
rs2471231897	3:23,960,902	A/C	—	likely benign
rs748865914	3:23,960,908	C/T	—	likely benign
rs774572575	3:23,960,913	A/G	—	uncertain significance
rs2471232003	3:23,960,917	C/A	—	uncertain significance
rs376990079	3:23,960,940	G/A	—	uncertain significance

Showing 100 of 118 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.