SEMA4D

semaphorin 4D

Summary

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of neuron projection development; and regulation of primary metabolic process. Located in microtubule organizing center; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants99 total

rsidPosition (GRCh37)AllelesClassClinVar
rs132953059:91,978,397C/Tbenign
rs2005108709:91,978,764G/Alikely benign
rs455151929:91,978,783G/Abenign
rs1399248539:91,991,853C/Abenign
rs2022114529:91,991,867G/Alikely benign
rs736547719:91,993,615G/Abenign
rs25478675549:91,993,675G/Cuncertain significance
rs7626307659:91,993,696C/Tuncertain significance
rs454833939:91,993,724T/Cbenign
rs25478686309:91,993,756C/Tuncertain significance
rs7548273909:91,993,808G/Alikely benign
rs12915891459:91,993,813A/Guncertain significance
rs14657165529:91,993,830A/Guncertain significance
rs1135111879:91,993,832C/Tlikely benign
rs1466236459:91,993,833G/Auncertain significance
rs8795233419:91,993,846T/Cuncertain significance
rs7678894489:91,993,854C/Tuncertain significance
rs1414407569:91,993,855G/Alikely benign
rs1383978879:91,994,003G/Alikely benign
rs3741188489:91,994,007C/Tuncertain significance
rs795223309:91,994,026G/Abenign
rs626387269:91,994,101A/Gbenign
rs2001271589:91,994,149C/Tuncertain significance
rs1397122489:91,994,157G/Auncertain significance
rs1493753869:91,994,158T/Cuncertain significance
rs2013983939:91,994,199G/Auncertain significance
rs18364709519:91,994,238G/Tuncertain significance
rs14839567969:91,994,274T/Cuncertain significance
rs10493539779:91,994,351A/Cuncertain significance
rs454644949:91,994,433T/Cbenign
rs7490169319:91,994,457C/Tlikely benign
rs1470861699:91,994,524G/Abenign
rs1997074889:91,996,096G/Auncertain significance
rs7629456229:91,996,111G/Auncertain significance
rs626387239:91,996,114G/Cbenign
rs1459200589:91,996,120C/Tlikely benign
rs1388591269:91,996,127C/Tlikely benign
rs7461917119:91,996,133G/Tlikely benign
rs7580816819:91,996,137G/Auncertain significance
rs1482988099:91,996,196C/Tlikely benign
rs7589408929:91,996,212G/Auncertain significance
rs12397087639:91,996,250A/Cuncertain significance
rs1508280499:92,001,303G/Alikely benign
rs7722017239:92,001,316T/Cuncertain significance
rs2010970539:92,001,320A/Guncertain significance
rs7709344779:92,001,359C/Tuncertain significance
rs734840279:92,002,292G/Abenign
rs5752097309:92,002,356C/Tlikely benign
rs5421145249:92,002,361C/Tuncertain significance
rs1401506799:92,002,381T/Auncertain significance
rs7709521679:92,002,415G/Tuncertain significance
rs7586689739:92,002,462G/Auncertain significance
rs3749015969:92,002,505G/Auncertain significance
rs7512359869:92,003,564G/Auncertain significance
rs25480325519:92,003,566C/Auncertain significance
rs5346712769:92,003,588C/Tuncertain significance
rs1509373249:92,003,653C/Glikely benign
rs115264689:92,003,679C/Tmissense variantbenign
rs1179091869:92,003,689C/Tbenign
rs7688336199:92,003,700C/Tuncertain significance
rs5575752859:92,003,711G/Clikely benign
rs1478224909:92,003,793G/Auncertain significance
rs25480379479:92,003,800A/Guncertain significance
rs7700187029:92,003,846G/Alikely benign
rs7582003659:92,003,940G/Auncertain significance
rs25480414569:92,003,956G/Cuncertain significance
rs11985538549:92,006,207A/Tuncertain significance
rs1436432199:92,006,211C/Abenign
rs283771689:92,006,275G/Abenign
rs2004606979:92,006,280C/Tuncertain significance
rs1168334249:92,006,281G/Abenign
rs1388674899:92,006,300C/Tuncertain significance
rs7761617839:92,006,301G/Auncertain significance
rs626387279:92,006,308G/Abenign
rs132878039:92,006,536C/A
rs1508822639:92,007,351G/Alikely benign
rs7815824999:92,007,377T/Cuncertain significance
rs3741449749:92,007,450A/Glikely benign
rs12586987679:92,011,701G/Cuncertain significance
rs48770809:92,013,728T/G
rs25481976389:92,014,222G/Cuncertain significance
rs25481977049:92,014,225T/Guncertain significance
rs18416842379:92,014,238A/Cuncertain significance
rs3743288459:92,014,256G/Alikely benign
rs112659049:92,014,868G/Aintron variant
rs412873619:92,017,733G/Aintron variant
rs21336389999:92,017,794G/Auncertain significance
rs626202289:92,017,815C/Tuncertain significance
rs9496215369:92,017,817T/Cuncertain significance
rs132844049:92,017,824C/Amissense variantbenign
rs7757892909:92,017,869C/Tuncertain significance
rs5760026029:92,017,914A/Guncertain significance
rs1408733729:92,020,304G/Auncertain significance
rs5527383299:92,020,310G/Auncertain significance
rs13553847009:92,020,362A/Cuncertain significance
rs563397129:92,025,757C/Tregulatory region variant
rs41326999:92,036,427A/Cupstream gene variant
rs1501587299:92,066,702G/Adownstream gene variant
rs800684159:92,093,127T/Cregulatory region variant

Gene information from NCBI Gene. Variant classifications from ClinVar.