SEMA4D

semaphorin 4D

Summary

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of neuron projection development; and regulation of primary metabolic process. Located in microtubule organizing center; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants99 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs13295305	9:91,978,397	C/T	—	benign
rs200510870	9:91,978,764	G/A	—	likely benign
rs45515192	9:91,978,783	G/A	—	benign
rs139924853	9:91,991,853	C/A	—	benign
rs202211452	9:91,991,867	G/A	—	likely benign
rs73654771	9:91,993,615	G/A	—	benign
rs2547867554	9:91,993,675	G/C	—	uncertain significance
rs762630765	9:91,993,696	C/T	—	uncertain significance
rs45483393	9:91,993,724	T/C	—	benign
rs2547868630	9:91,993,756	C/T	—	uncertain significance
rs754827390	9:91,993,808	G/A	—	likely benign
rs1291589145	9:91,993,813	A/G	—	uncertain significance
rs1465716552	9:91,993,830	A/G	—	uncertain significance
rs113511187	9:91,993,832	C/T	—	likely benign
rs146623645	9:91,993,833	G/A	—	uncertain significance
rs879523341	9:91,993,846	T/C	—	uncertain significance
rs767889448	9:91,993,854	C/T	—	uncertain significance
rs141440756	9:91,993,855	G/A	—	likely benign
rs138397887	9:91,994,003	G/A	—	likely benign
rs374118848	9:91,994,007	C/T	—	uncertain significance
rs79522330	9:91,994,026	G/A	—	benign
rs62638726	9:91,994,101	A/G	—	benign
rs200127158	9:91,994,149	C/T	—	uncertain significance
rs139712248	9:91,994,157	G/A	—	uncertain significance
rs149375386	9:91,994,158	T/C	—	uncertain significance
rs201398393	9:91,994,199	G/A	—	uncertain significance
rs1836470951	9:91,994,238	G/T	—	uncertain significance
rs1483956796	9:91,994,274	T/C	—	uncertain significance
rs1049353977	9:91,994,351	A/C	—	uncertain significance
rs45464494	9:91,994,433	T/C	—	benign
rs749016931	9:91,994,457	C/T	—	likely benign
rs147086169	9:91,994,524	G/A	—	benign
rs199707488	9:91,996,096	G/A	—	uncertain significance
rs762945622	9:91,996,111	G/A	—	uncertain significance
rs62638723	9:91,996,114	G/C	—	benign
rs145920058	9:91,996,120	C/T	—	likely benign
rs138859126	9:91,996,127	C/T	—	likely benign
rs746191711	9:91,996,133	G/T	—	likely benign
rs758081681	9:91,996,137	G/A	—	uncertain significance
rs148298809	9:91,996,196	C/T	—	likely benign
rs758940892	9:91,996,212	G/A	—	uncertain significance
rs1239708763	9:91,996,250	A/C	—	uncertain significance
rs150828049	9:92,001,303	G/A	—	likely benign
rs772201723	9:92,001,316	T/C	—	uncertain significance
rs201097053	9:92,001,320	A/G	—	uncertain significance
rs770934477	9:92,001,359	C/T	—	uncertain significance
rs73484027	9:92,002,292	G/A	—	benign
rs575209730	9:92,002,356	C/T	—	likely benign
rs542114524	9:92,002,361	C/T	—	uncertain significance
rs140150679	9:92,002,381	T/A	—	uncertain significance
rs770952167	9:92,002,415	G/T	—	uncertain significance
rs758668973	9:92,002,462	G/A	—	uncertain significance
rs374901596	9:92,002,505	G/A	—	uncertain significance
rs751235986	9:92,003,564	G/A	—	uncertain significance
rs2548032551	9:92,003,566	C/A	—	uncertain significance
rs534671276	9:92,003,588	C/T	—	uncertain significance
rs150937324	9:92,003,653	C/G	—	likely benign
rs11526468	9:92,003,679	C/T	missense variant	benign
rs117909186	9:92,003,689	C/T	—	benign
rs768833619	9:92,003,700	C/T	—	uncertain significance
rs557575285	9:92,003,711	G/C	—	likely benign
rs147822490	9:92,003,793	G/A	—	uncertain significance
rs2548037947	9:92,003,800	A/G	—	uncertain significance
rs770018702	9:92,003,846	G/A	—	likely benign
rs758200365	9:92,003,940	G/A	—	uncertain significance
rs2548041456	9:92,003,956	G/C	—	uncertain significance
rs1198553854	9:92,006,207	A/T	—	uncertain significance
rs143643219	9:92,006,211	C/A	—	benign
rs28377168	9:92,006,275	G/A	—	benign
rs200460697	9:92,006,280	C/T	—	uncertain significance
rs116833424	9:92,006,281	G/A	—	benign
rs138867489	9:92,006,300	C/T	—	uncertain significance
rs776161783	9:92,006,301	G/A	—	uncertain significance
rs62638727	9:92,006,308	G/A	—	benign
rs13287803	9:92,006,536	C/A	—	—
rs150882263	9:92,007,351	G/A	—	likely benign
rs781582499	9:92,007,377	T/C	—	uncertain significance
rs374144974	9:92,007,450	A/G	—	likely benign
rs1258698767	9:92,011,701	G/C	—	uncertain significance
rs4877080	9:92,013,728	T/G	—	—
rs2548197638	9:92,014,222	G/C	—	uncertain significance
rs2548197704	9:92,014,225	T/G	—	uncertain significance
rs1841684237	9:92,014,238	A/C	—	uncertain significance
rs374328845	9:92,014,256	G/A	—	likely benign
rs11265904	9:92,014,868	G/A	intron variant	—
rs41287361	9:92,017,733	G/A	intron variant	—
rs2133638999	9:92,017,794	G/A	—	uncertain significance
rs62620228	9:92,017,815	C/T	—	uncertain significance
rs949621536	9:92,017,817	T/C	—	uncertain significance
rs13284404	9:92,017,824	C/A	missense variant	benign
rs775789290	9:92,017,869	C/T	—	uncertain significance
rs576002602	9:92,017,914	A/G	—	uncertain significance
rs140873372	9:92,020,304	G/A	—	uncertain significance
rs552738329	9:92,020,310	G/A	—	uncertain significance
rs1355384700	9:92,020,362	A/C	—	uncertain significance
rs56339712	9:92,025,757	C/T	regulatory region variant	—
rs4132699	9:92,036,427	A/C	upstream gene variant	—
rs150158729	9:92,066,702	G/A	downstream gene variant	—
rs80068415	9:92,093,127	T/C	regulatory region variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.