rs28377168

This variant is located in the SEMA4D gene.

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ClinVar annotation

Benign
2 submitters

SEMA4D-related disorder; Colon adenocarcinoma; Ovarian serous cystadenocarcinoma; Malignant lymphoma, large B-cell, diffuse; Sarcoma; Melanoma; Nonpapillary renal cell carcinoma; Lung cancer

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About SEMA4D

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of neuron projection development; and regulation of primary metabolic process. Located in microtubule organizing center; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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