SFRP1
secreted frizzled related protein 1
Summary
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3242 | 8:41,119,554 | G/A | 3 prime UTR variant | — |
| rs1127379 | 8:41,121,280 | T/C | 3 prime UTR variant | — |
| rs765603358 | 8:41,122,697 | C/T | — | uncertain significance |
| rs1064796559 | 8:41,122,818 | C/T | — | uncertain significance |
| rs752829505 | 8:41,122,871 | C/T | — | uncertain significance |
| rs142720509 | 8:41,122,934 | G/C | — | uncertain significance |
| rs151006069 | 8:41,122,939 | T/G | — | uncertain significance |
| rs10092343 | 8:41,123,477 | G/C | intron variant | — |
| rs531826045 | 8:41,134,029 | T/A | — | — |
| rs11786528 | 8:41,143,063 | G/A | intron variant | — |
| rs7832767 | 8:41,159,859 | C/T | downstream gene variant | — |
| rs2486737914 | 8:41,160,999 | A/T | — | uncertain significance |
| rs146935086 | 8:41,161,051 | G/A | — | uncertain significance |
| rs143342404 | 8:41,164,544 | T/C | intron variant | — |
| rs768990544 | 8:41,166,159 | C/T | — | uncertain significance |
| rs763220830 | 8:41,166,177 | C/A | — | uncertain significance |
| rs766598576 | 8:41,166,178 | G/C | — | uncertain significance |
| rs745540217 | 8:41,166,230 | T/C | — | uncertain significance |
| rs76486417 | 8:41,166,435 | G/A | — | benign |
| rs2486747215 | 8:41,166,491 | G/A | — | likely benign |
| rs184528079 | 8:41,166,523 | G/A | — | benign |
| rs771249090 | 8:41,166,530 | C/G | — | uncertain significance |
| rs1804035140 | 8:41,166,543 | A/G | — | uncertain significance |
| rs772267698 | 8:41,166,545 | G/C | — | uncertain significance |
| rs62636770 | 8:41,166,674 | C/A | — | uncertain significance |
| rs72643819 | 8:41,167,193 | G/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.