SGPP2
sphingosine-1-phosphate phosphatase 2
Summary
The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1485412980 | 2:223,289,341 | G/A | — | uncertain significance |
| rs892523376 | 2:223,289,406 | G/A | — | uncertain significance |
| rs2469166997 | 2:223,289,445 | G/A | — | uncertain significance |
| rs964286756 | 2:223,289,451 | C/T | — | uncertain significance |
| rs1204241406 | 2:223,289,485 | A/G | — | uncertain significance |
| rs146446086 | 2:223,322,736 | G/A | upstream gene variant | — |
| rs2469223751 | 2:223,339,288 | C/T | — | uncertain significance |
| rs138702204 | 2:223,339,308 | G/A | — | uncertain significance |
| rs763746109 | 2:223,339,351 | C/T | — | uncertain significance |
| rs139808623 | 2:223,339,378 | C/T | — | uncertain significance |
| rs17496827 | 2:223,353,446 | A/C | intron variant | — |
| rs1362428278 | 2:223,354,294 | A/T | — | — |
| rs746343935 | 2:223,423,093 | G/A | — | uncertain significance |
| rs753641700 | 2:223,423,115 | A/T | — | uncertain significance |
| rs368194576 | 2:223,423,238 | G/A | — | uncertain significance |
| rs768924813 | 2:223,423,241 | C/T | — | uncertain significance |
| rs752447677 | 2:223,423,284 | A/G | — | uncertain significance |
| rs371268936 | 2:223,423,432 | C/T | — | uncertain significance |
| rs1689466612 | 2:223,423,444 | C/A | — | uncertain significance |
| rs141391402 | 2:223,423,510 | C/G | — | uncertain significance |
| rs151021147 | 2:223,423,511 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.