SHB
SH2 domain containing adaptor protein B
Summary
Enables phosphotyrosine residue binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3747547 | 9:37,916,408 | T/C | downstream gene variant | — |
| rs11998861 | 9:37,919,839 | G/A | — | benign |
| rs377422700 | 9:37,919,922 | C/T | — | uncertain significance |
| rs184250370 | 9:37,919,926 | C/T | — | benign |
| rs757994284 | 9:37,919,977 | C/T | — | uncertain significance |
| rs979211013 | 9:37,948,645 | A/C | — | uncertain significance |
| rs540395778 | 9:37,948,652 | A/T | — | uncertain significance |
| rs755295306 | 9:37,948,735 | T/C | — | uncertain significance |
| rs10732358 | 9:37,954,913 | G/A | intron variant | — |
| rs771663282 | 9:37,955,919 | C/T | — | uncertain significance |
| rs551674245 | 9:37,955,982 | C/A | — | uncertain significance |
| rs746505733 | 9:37,955,995 | G/A | — | uncertain significance |
| rs544312545 | 9:37,959,666 | G/T | — | — |
| rs7872846 | 9:37,974,642 | C/T | — | uncertain significance |
| rs2117966708 | 9:37,974,658 | G/A | — | uncertain significance |
| rs1354134251 | 9:37,974,676 | C/T | — | uncertain significance |
| rs752142144 | 9:37,974,686 | G/A | — | likely benign |
| rs755704312 | 9:37,974,704 | G/C | — | uncertain significance |
| rs749259021 | 9:37,974,712 | G/A | — | uncertain significance |
| rs10738990 | 9:37,975,921 | C/G | — | — |
| rs4878734 | 9:38,010,085 | A/T | intron variant | — |
| rs1443988909 | 9:38,016,060 | C/A | — | uncertain significance |
| rs10283803 | 9:38,019,145 | T/C | regulatory region variant | — |
| rs7873102 | 9:38,041,142 | T/G | intron variant | — |
| rs1347073588 | 9:38,067,927 | T/C | — | uncertain significance |
| rs767360138 | 9:38,067,928 | T/C | — | uncertain significance |
| rs2490453061 | 9:38,067,946 | C/T | — | uncertain significance |
| rs918729197 | 9:38,067,955 | C/T | — | uncertain significance |
| rs754051968 | 9:38,067,957 | G/C | — | uncertain significance |
| rs1821992663 | 9:38,067,964 | A/G | — | uncertain significance |
| rs747385431 | 9:38,067,967 | C/G | — | uncertain significance |
| rs1367655766 | 9:38,067,976 | T/C | — | uncertain significance |
| rs2489232777 | 9:38,068,018 | T/A | — | uncertain significance |
| rs574056272 | 9:38,068,104 | G/A | — | uncertain significance |
| rs752056534 | 9:38,068,106 | G/C | — | uncertain significance |
| rs1160718444 | 9:38,068,107 | A/G | — | uncertain significance |
| rs2489233145 | 9:38,068,125 | G/A | — | uncertain significance |
| rs199974314 | 9:38,068,162 | G/A | — | uncertain significance |
| rs781249635 | 9:38,068,176 | G/C | — | uncertain significance |
| rs749534151 | 9:38,068,189 | A/C | — | uncertain significance |
| rs1459766699 | 9:38,068,203 | C/G | — | uncertain significance |
| rs2489233545 | 9:38,068,222 | A/G | — | uncertain significance |
| rs901970820 | 9:38,068,261 | A/G | — | uncertain significance |
| rs766123390 | 9:38,068,272 | A/G | — | uncertain significance |
| rs377233293 | 9:38,068,274 | C/T | — | likely benign |
| rs1822002025 | 9:38,068,281 | G/A | — | uncertain significance |
| rs746256744 | 9:38,068,308 | A/C | — | uncertain significance |
| rs774688987 | 9:38,068,316 | C/T | — | uncertain significance |
| rs760234854 | 9:38,068,423 | T/C | — | uncertain significance |
| rs1822005706 | 9:38,068,427 | G/T | — | uncertain significance |
| rs368163067 | 9:38,068,454 | G/A | — | benign |
| rs897677193 | 9:38,068,512 | A/G | — | uncertain significance |
| rs199903163 | 9:38,068,515 | G/A | — | uncertain significance |
| rs756635370 | 9:38,068,524 | G/T | — | uncertain significance |
| rs1480663639 | 9:38,068,548 | C/T | — | uncertain significance |
| rs1187099479 | 9:38,068,605 | T/C | — | uncertain significance |
| rs766207159 | 9:38,068,614 | C/T | — | uncertain significance |
| rs3808862 | 9:38,070,583 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.