SIGLEC1

sialic acid binding Ig like lectin 1

Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021]

Known Variants158 total

rsidPosition (GRCh37)AllelesClassClinVar
rs18856564220:3,667,676C/Tregulatory region variant—
rs178513106420:3,669,262A/G—uncertain significance
rs77483272020:3,669,834C/T—uncertain significance
rs14727741520:3,669,843C/G—conflicting classifications of pathogenicity
rs811567920:3,670,646C/T—benign
rs37132471620:3,670,773T/A—uncertain significance
rs126015717220:3,670,818G/A—uncertain significance
rs142651127520:3,670,839C/T—uncertain significance
rs251496011720:3,670,860A/T—uncertain significance
rs147500425020:3,671,999G/A—uncertain significance
rs14348922220:3,672,046C/T—likely benign
rs14174458420:3,672,056T/G—likely benign
rs77785241920:3,672,070C/T—uncertain significance
rs78154284520:3,672,077C/T—uncertain significance
rs78024680120:3,672,089C/T—likely benign
rs13852136720:3,672,110C/T—likely benign
rs76623646120:3,672,118C/T—likely benign
rs3570220820:3,672,123G/A—likely benign
rs124604614820:3,672,134A/G—uncertain significance
rs75624727820:3,672,144G/T—likely benign
rs37747885320:3,672,169C/T—uncertain significance
rs75041697620:3,672,227G/A—uncertain significance
rs75475974020:3,672,569G/A—likely benign
rs74554856820:3,672,570A/G—likely benign
rs75577116220:3,672,651C/T—uncertain significance
rs20053965220:3,672,652G/A—conflicting classifications of pathogenicity
rs14603503420:3,672,717G/T—likely benign
rs77952135120:3,672,738T/A—uncertain significance
rs160028025920:3,672,827C/G—likely benign
rs19971398520:3,673,191C/T—uncertain significance
rs57674277920:3,673,207C/T—uncertain significance
rs36958264120:3,673,225G/C—uncertain significance
rs54181297620:3,673,251C/T—uncertain significance
rs208877603820:3,673,268T/G—likely benign
rs74718603120:3,673,272A/G—uncertain significance
rs20013724420:3,673,296A/Gmissense variant—
rs76067644320:3,673,312G/A—uncertain significance
rs251496561120:3,673,323T/C—uncertain significance
rs37465239120:3,673,335G/C—uncertain significance
rs75737198820:3,673,336C/G—likely benign
rs20127502820:3,673,352C/T—likely benign
rs77396210520:3,673,363C/A—uncertain significance
rs119261344120:3,673,383G/T—uncertain significance
rs14258211720:3,673,535T/C—likely benign
rs19963625820:3,673,557G/A—likely benign
rs75888829520:3,673,613C/T—uncertain significance
rs117459288520:3,673,614G/A—uncertain significance
rs14600789820:3,673,643G/Amissense variant—
rs77343303620:3,673,659G/A—uncertain significance
rs20115577420:3,673,721G/A—uncertain significance
rs77487837620:3,673,761G/A—uncertain significance
rs76612344220:3,673,773G/A—uncertain significance
rs14510864620:3,673,775G/A—uncertain significance
rs251496783020:3,674,096A/G—uncertain significance
rs37626016120:3,674,126C/T—likely benign
rs75142561320:3,674,127G/T—uncertain significance
rs76880754420:3,674,136G/A—uncertain significance
rs77595901620:3,674,159C/T—uncertain significance
rs75927852720:3,674,160G/A—conflicting classifications of pathogenicity
rs129658970720:3,674,184T/A—uncertain significance
rs77916612020:3,674,202T/G—uncertain significance
rs75271952820:3,674,319C/T—likely benign
rs7952566420:3,674,875G/A—benign
rs77755379020:3,674,893C/T—likely benign
rs251497028320:3,675,020T/G—likely benign
rs99252230220:3,675,024G/T—uncertain significance
rs74920827920:3,675,066C/T—uncertain significance
rs75100052220:3,675,100G/C—uncertain significance
rs75675439120:3,675,101T/A—uncertain significance
rs76725827220:3,675,107C/A—uncertain significance
rs75002059320:3,675,108G/A—uncertain significance
rs70902020:3,675,136G/A—benign
rs18558420020:3,675,345G/A—uncertain significance
rs251497163620:3,675,408G/A—uncertain significance
rs89274232920:3,675,503C/G—uncertain significance
rs251497210820:3,675,523C/T—uncertain significance
rs75384791320:3,675,529C/T—uncertain significance
rs52794220:3,676,788A/Cintron variant—
rs36816789920:3,677,325C/T—uncertain significance
rs20206317220:3,677,407C/T—uncertain significance
rs118023017920:3,677,433G/A—uncertain significance
rs86820843420:3,677,478G/A—uncertain significance
rs19974937120:3,677,785A/G—uncertain significance
rs57667919720:3,677,789G/A—uncertain significance
rs14581051420:3,677,796G/A—likely benign
rs76910300520:3,677,898G/T—uncertain significance
rs14267507220:3,677,915G/A—uncertain significance
rs20060708420:3,677,942C/T—uncertain significance
rs20203179320:3,677,947C/T—uncertain significance
rs208781078720:3,677,954G/C—uncertain significance
rs89829113220:3,677,975T/C—uncertain significance
rs75001966220:3,678,510A/G—uncertain significance
rs74809076520:3,678,550G/A—uncertain significance
rs74599852720:3,678,562G/A—uncertain significance
rs14947821520:3,678,574C/A—uncertain significance
rs75087512920:3,678,595C/A—uncertain significance
rs14480383120:3,678,605G/A—likely benign
rs76994391120:3,678,646G/A—uncertain significance
rs74937016120:3,678,649C/T—uncertain significance
rs129931187920:3,678,668C/A—uncertain significance

Showing 100 of 158 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.