rs143489222

This variant is located in the SIGLEC1 gene.

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GWAS Catalog Trait Associations (16)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sialoadhesin measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.97
p 1.0e-155
N 47,745
Large GWAS
European

galectin-3-binding protein measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.64
p 5.0e-69
N 47,745
Large GWAS
European

level of angiopoietin-related protein 2 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.56
p 7.0e-54
N 47,745
Large GWAS
European

level of polycystin-1 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.48
p 2.0e-44
N 47,745
Large GWAS
European

level of immunoglobulin superfamily member 2 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.32
p 1.0e-25
N 47,745
Large GWAS
European

protein HEG homolog 1 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.29
p 2.0e-18
N 47,745
Large GWAS
European
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ClinVar annotation

Likely Benign★☆☆☆
1 submitter
View on ClinVar →

About SIGLEC1

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021]

View all SIGLEC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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