SIGLEC15
sialic acid binding Ig like lectin 15
Summary
Predicted to be involved in regulation of actin cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants30 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs529088073 | 18:43,405,728 | C/T | — | likely benign |
| rs143499176 | 18:43,417,031 | C/G | — | uncertain significance |
| rs2048281404 | 18:43,417,034 | G/C | — | uncertain significance |
| rs1205319404 | 18:43,417,478 | G/T | — | uncertain significance |
| rs2511379828 | 18:43,417,523 | G/C | — | uncertain significance |
| rs2511379875 | 18:43,417,535 | G/A | — | uncertain significance |
| rs528604727 | 18:43,417,550 | T/G | — | uncertain significance |
| rs749362975 | 18:43,417,555 | T/G | — | uncertain significance |
| rs550831965 | 18:43,417,604 | T/C | — | uncertain significance |
| rs754507289 | 18:43,417,658 | C/T | — | uncertain significance |
| rs533118109 | 18:43,417,661 | G/C | — | uncertain significance |
| rs777583258 | 18:43,417,698 | C/G | — | uncertain significance |
| rs1303956994 | 18:43,417,747 | C/A | — | uncertain significance |
| rs1408072461 | 18:43,417,753 | G/C | — | uncertain significance |
| rs781000376 | 18:43,417,837 | C/T | — | uncertain significance |
| rs200427190 | 18:43,418,689 | C/G | — | uncertain significance |
| rs746164935 | 18:43,418,719 | G/C | — | uncertain significance |
| rs749688384 | 18:43,418,721 | C/G | — | uncertain significance |
| rs769258846 | 18:43,418,724 | G/A | — | uncertain significance |
| rs2048298784 | 18:43,418,737 | G/A | — | uncertain significance |
| rs201942536 | 18:43,418,791 | C/A | — | uncertain significance |
| rs780451018 | 18:43,418,792 | G/A | — | likely benign |
| rs2511383868 | 18:43,418,799 | G/T | — | uncertain significance |
| rs371122869 | 18:43,418,817 | G/A | — | uncertain significance |
| rs1262321434 | 18:43,418,859 | G/A | — | uncertain significance |
| rs779280228 | 18:43,418,886 | C/G | — | uncertain significance |
| rs2919643 | 18:43,419,003 | T/C | — | benign |
| rs768038830 | 18:43,419,010 | C/T | — | uncertain significance |
| rs61995716 | 18:43,419,041 | C/T | — | likely benign |
| rs143689799 | 18:43,422,149 | G/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.