SIGLEC5
sialic acid binding Ig like lectin 5
Summary
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs74861892 | 19:52,115,085 | T/A | downstream gene variant | — |
| rs759409207 | 19:52,115,642 | C/T | — | uncertain significance |
| rs2514171103 | 19:52,115,659 | G/C | — | uncertain significance |
| rs2514171119 | 19:52,115,665 | T/C | — | uncertain significance |
| rs12462938 | 19:52,115,833 | A/G | intron variant | — |
| rs12984737 | 19:52,118,441 | G/A | intron variant | — |
| rs181481353 | 19:52,120,328 | G/A | upstream gene variant | — |
| rs10414149 | 19:52,127,744 | A/G | downstream gene variant | — |
| rs6509558 | 19:52,127,949 | C/T | downstream gene variant | — |
| rs144080278 | 19:52,128,050 | C/T | downstream gene variant | — |
| rs746633265 | 19:52,129,286 | G/A | — | uncertain significance |
| rs764161336 | 19:52,129,328 | T/A | — | uncertain significance |
| rs17852719 | 19:52,130,487 | C/T | — | likely benign |
| rs1106476 | 19:52,130,637 | T/A | intron variant | — |
| rs1983533408 | 19:52,130,763 | C/T | — | uncertain significance |
| rs147941959 | 19:52,130,850 | C/T | — | uncertain significance |
| rs772906943 | 19:52,130,921 | G/C | — | uncertain significance |
| rs200372912 | 19:52,130,940 | A/G | — | uncertain significance |
| rs376401216 | 19:52,130,990 | T/A | — | uncertain significance |
| rs767883806 | 19:52,131,128 | G/A | — | uncertain significance |
| rs2514195110 | 19:52,131,134 | T/C | — | uncertain significance |
| rs778716107 | 19:52,131,141 | G/C | — | uncertain significance |
| rs151263979 | 19:52,131,180 | G/A | — | uncertain significance |
| rs1467113675 | 19:52,131,197 | G/A | — | uncertain significance |
| rs199698179 | 19:52,131,206 | A/G | — | uncertain significance |
| rs759914871 | 19:52,131,269 | G/A | — | uncertain significance |
| rs761011703 | 19:52,131,287 | C/T | — | likely benign |
| rs61736487 | 19:52,131,296 | T/C | — | benign |
| rs765090595 | 19:52,131,311 | G/A | — | likely benign |
| rs750425480 | 19:52,131,314 | A/T | — | uncertain significance |
| rs747328477 | 19:52,132,297 | C/A | — | uncertain significance |
| rs144851057 | 19:52,132,298 | G/A | — | benign |
| rs1983624084 | 19:52,132,311 | G/A | — | uncertain significance |
| rs774340778 | 19:52,132,667 | A/T | — | uncertain significance |
| rs570881417 | 19:52,132,733 | G/A | — | uncertain significance |
| rs772339797 | 19:52,132,743 | G/T | — | uncertain significance |
| rs772930577 | 19:52,132,788 | G/A | — | uncertain significance |
| rs2278832 | 19:52,132,986 | A/C | — | — |
| rs777669740 | 19:52,133,145 | T/C | — | uncertain significance |
| rs773993688 | 19:52,133,152 | G/A | — | uncertain significance |
| rs199864224 | 19:52,133,191 | C/T | — | likely benign |
| rs2514200576 | 19:52,133,239 | A/C | — | uncertain significance |
| rs201664362 | 19:52,133,270 | G/T | missense variant | — |
| rs1973019 | 19:52,133,292 | A/G | missense variant | — |
| rs1264119810 | 19:52,133,361 | G/C | — | uncertain significance |
| rs1169498794 | 19:52,133,421 | A/G | — | uncertain significance |
| rs778734174 | 19:52,133,563 | A/G | — | uncertain significance |
| rs137883522 | 19:52,134,542 | A/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.