SIGLEC6
sialic acid binding Ig like lectin 6
Summary
This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1237553594 | 19:52,023,371 | C/T | — | likely benign |
| rs770259451 | 19:52,023,377 | C/A | — | uncertain significance |
| rs771497934 | 19:52,023,467 | G/T | — | uncertain significance |
| rs930097708 | 19:52,023,488 | T/C | — | uncertain significance |
| rs771982211 | 19:52,023,887 | C/T | — | — |
| rs563918580 | 19:52,031,021 | C/T | — | uncertain significance |
| rs1979559369 | 19:52,031,439 | A/C | — | uncertain significance |
| rs182869426 | 19:52,031,483 | C/T | — | benign |
| rs1979569281 | 19:52,031,490 | C/T | — | uncertain significance |
| rs546008319 | 19:52,032,489 | C/T | — | — |
| rs4146202 | 19:52,032,668 | T/A | — | — |
| rs894438184 | 19:52,033,106 | G/A | — | uncertain significance |
| rs370040093 | 19:52,033,107 | C/A | — | uncertain significance |
| rs2305771 | 19:52,033,572 | T/C | intron variant | — |
| rs773600039 | 19:52,033,952 | A/G | — | uncertain significance |
| rs180865472 | 19:52,033,967 | G/T | missense variant | — |
| rs186522588 | 19:52,033,974 | C/T | — | uncertain significance |
| rs200369206 | 19:52,034,112 | G/A | — | uncertain significance |
| rs780557269 | 19:52,034,114 | G/A | — | uncertain significance |
| rs2514069890 | 19:52,034,120 | T/C | — | uncertain significance |
| rs545960270 | 19:52,034,189 | G/C | — | uncertain significance |
| rs201650877 | 19:52,034,437 | G/A | — | uncertain significance |
| rs1980281426 | 19:52,034,450 | C/T | — | uncertain significance |
| rs201997695 | 19:52,034,459 | T/A | — | uncertain significance |
| rs765293154 | 19:52,034,522 | T/C | — | uncertain significance |
| rs202046841 | 19:52,034,531 | A/G | — | uncertain significance |
| rs62617068 | 19:52,034,549 | C/A | — | benign |
| rs1027571676 | 19:52,034,573 | G/A | — | uncertain significance |
| rs74546168 | 19:52,034,685 | T/C | synonymous variant | — |
| rs774556009 | 19:52,034,693 | G/A | — | uncertain significance |
| rs569609721 | 19:52,034,729 | A/C | — | uncertain significance |
| rs76001696 | 19:52,034,839 | C/G | — | benign |
| rs76506690 | 19:52,035,146 | C/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.