rs62617068

This variant is located in the SIGLEC6 gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sialic acid-binding Ig-like lectin 6 amount

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele A

OR 1.09

p 1.0e-41

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

▶

ClinVar annotation

Benign★★★☆

4 submitters2 publications

not provided; Malignant lymphoma, large B-cell, diffuse; Thyroid cancer, nonmedullary, 1; Lung cancer; Familial cancer of breast; Clear cell carcinoma of kidney; Uterine corpus endometrial carcinoma

View on ClinVar →

About SIGLEC6

This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

View all SIGLEC6 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…