SLC25A5

solute carrier family 25 member 5

Summary

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

Known Variants25 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs392020	X:118,601,473	T/A	coding sequence variant	—
rs759855460	X:118,602,482	A/G	—	uncertain significance
rs766261593	X:118,603,650	T/C	—	likely benign
rs113618375	X:118,603,668	A/G	—	likely benign
rs201182381	X:118,603,713	T/C	—	likely benign
rs1419542110	X:118,603,715	T/C	—	uncertain significance
rs148920941	X:118,603,773	T/C	—	likely benign
rs77766798	X:118,603,818	T/G	—	likely benign
rs73637847	X:118,603,830	A/G	—	likely benign
rs2521435168	X:118,603,832	C/T	—	uncertain significance
rs371749	X:118,603,844	T/G	—	benign
rs375406763	X:118,603,869	G/A	—	benign
rs756320158	X:118,603,872	T/C	—	benign
rs753913830	X:118,603,873	G/T	—	benign
rs779172013	X:118,603,881	A/T	—	benign
rs2521435467	X:118,603,962	T/G	—	likely benign
rs2521435537	X:118,604,001	G/A	—	likely benign
rs776004478	X:118,604,036	A/T	—	uncertain significance
rs116700864	X:118,604,400	T/G	—	likely benign
rs201855156	X:118,604,409	C/T	—	likely benign
rs200133814	X:118,604,412	G/A	—	likely benign
rs73213195	X:118,605,001	G/T	—	benign
rs80323990	X:118,605,012	G/C	—	benign
rs77294853	X:118,605,017	C/T	—	benign
rs74343587	X:118,605,023	T/G	—	benign

Gene information from NCBI Gene. Variant classifications from ClinVar.