SLIT1
slit guidance ligand 1
Summary
Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants92 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs757092109 | 10:98,760,874 | C/G | — | uncertain significance |
| rs774592049 | 10:98,760,916 | C/T | — | uncertain significance |
| rs147599893 | 10:98,760,970 | G/A | — | uncertain significance |
| rs1848305223 | 10:98,761,000 | A/G | — | uncertain significance |
| rs569405132 | 10:98,761,002 | G/A | — | uncertain significance |
| rs116713666 | 10:98,761,008 | C/T | — | uncertain significance |
| rs148906362 | 10:98,761,032 | C/T | — | uncertain significance |
| rs961441467 | 10:98,761,072 | G/T | — | uncertain significance |
| rs762679751 | 10:98,761,081 | G/A | — | uncertain significance |
| rs267602656 | 10:98,761,930 | C/T | — | uncertain significance |
| rs377310191 | 10:98,761,958 | G/C | — | uncertain significance |
| rs575734584 | 10:98,761,967 | C/A | — | uncertain significance |
| rs2493054962 | 10:98,761,992 | C/T | — | uncertain significance |
| rs760261300 | 10:98,762,008 | G/C | — | uncertain significance |
| rs1372469110 | 10:98,762,010 | C/T | — | uncertain significance |
| rs760012723 | 10:98,762,035 | C/T | — | uncertain significance |
| rs201999932 | 10:98,762,036 | G/A | — | likely benign |
| rs1442251445 | 10:98,762,097 | T/C | — | uncertain significance |
| rs1281236527 | 10:98,762,098 | C/T | — | uncertain significance |
| rs199870948 | 10:98,762,099 | G/A | — | likely benign |
| rs1848318500 | 10:98,762,101 | G/A | — | uncertain significance |
| rs758291717 | 10:98,762,107 | C/G | — | uncertain significance |
| rs1363353276 | 10:98,762,589 | G/C | — | uncertain significance |
| rs1276643878 | 10:98,762,716 | C/T | — | uncertain significance |
| rs774613268 | 10:98,763,846 | C/T | — | uncertain significance |
| rs780115071 | 10:98,764,495 | C/T | — | uncertain significance |
| rs2493060854 | 10:98,766,257 | C/A | — | uncertain significance |
| rs755290344 | 10:98,766,259 | C/T | — | uncertain significance |
| rs140121402 | 10:98,770,783 | T/C | — | uncertain significance |
| rs2493069759 | 10:98,773,508 | C/T | — | uncertain significance |
| rs935780033 | 10:98,773,529 | C/T | — | uncertain significance |
| rs368735315 | 10:98,773,784 | T/C | — | uncertain significance |
| rs769023200 | 10:98,773,805 | T/C | — | uncertain significance |
| rs2493070571 | 10:98,773,898 | C/T | — | uncertain significance |
| rs116028202 | 10:98,773,918 | G/T | — | benign |
| rs12246721 | 10:98,773,922 | G/A | — | benign |
| rs2493076626 | 10:98,778,747 | C/T | — | uncertain significance |
| rs375574012 | 10:98,778,782 | G/T | — | uncertain significance |
| rs201572133 | 10:98,778,784 | C/T | — | uncertain significance |
| rs770623464 | 10:98,778,855 | G/A | — | uncertain significance |
| rs763444549 | 10:98,781,033 | G/A | — | uncertain significance |
| rs765149937 | 10:98,790,533 | C/T | — | uncertain significance |
| rs139410931 | 10:98,790,539 | C/T | — | uncertain significance |
| rs1037149277 | 10:98,791,405 | A/G | — | uncertain significance |
| rs754743304 | 10:98,791,406 | T/C | — | uncertain significance |
| rs11591691 | 10:98,791,439 | G/A | — | likely benign |
| rs12773465 | 10:98,794,059 | A/G | intron variant | — |
| rs571704169 | 10:98,794,253 | T/C | — | uncertain significance |
| rs150920866 | 10:98,797,456 | C/T | — | uncertain significance |
| rs767997642 | 10:98,797,500 | G/A | — | uncertain significance |
| rs2493101808 | 10:98,799,766 | A/T | — | likely pathogenic |
| rs773799100 | 10:98,799,842 | A/G | — | uncertain significance |
| rs745368256 | 10:98,799,844 | T/A | — | uncertain significance |
| rs1196861457 | 10:98,799,877 | C/G | — | uncertain significance |
| rs3824789 | 10:98,800,099 | G/T | — | — |
| rs144930720 | 10:98,802,756 | C/T | — | uncertain significance |
| rs746138250 | 10:98,802,758 | C/T | — | likely benign |
| rs138858154 | 10:98,802,763 | G/A | — | uncertain significance |
| rs760025670 | 10:98,806,457 | A/T | — | uncertain significance |
| rs199925095 | 10:98,806,502 | C/T | — | uncertain significance |
| rs200878365 | 10:98,807,588 | G/A | — | uncertain significance |
| rs528766038 | 10:98,808,605 | C/G | — | — |
| rs73320652 | 10:98,808,746 | G/T | — | benign |
| rs760110207 | 10:98,808,787 | C/T | — | uncertain significance |
| rs757253587 | 10:98,808,841 | T/C | — | uncertain significance |
| rs897480539 | 10:98,808,859 | G/A | — | uncertain significance |
| rs2805588 | 10:98,808,866 | C/G | — | benign |
| rs7902871 | 10:98,809,703 | A/G | intron variant | — |
| rs190394916 | 10:98,815,992 | C/T | regulatory region variant | — |
| rs200426634 | 10:98,816,108 | G/A | — | uncertain significance |
| rs777130364 | 10:98,817,004 | G/A | — | uncertain significance |
| rs769848205 | 10:98,817,011 | G/T | — | uncertain significance |
| rs756129650 | 10:98,820,403 | G/A | — | uncertain significance |
| rs776371715 | 10:98,823,232 | T/A | — | uncertain significance |
| rs148132859 | 10:98,823,275 | C/T | — | uncertain significance |
| rs534518230 | 10:98,823,277 | G/A | — | uncertain significance |
| rs116469159 | 10:98,823,963 | G/T | — | benign |
| rs758556942 | 10:98,824,578 | G/A | — | uncertain significance |
| rs1230021910 | 10:98,825,796 | C/T | — | uncertain significance |
| rs7072055 | 10:98,908,733 | C/A | intron variant | — |
| rs59474325 | 10:98,913,140 | C/T | intron variant | — |
| rs923070272 | 10:98,923,144 | C/G | — | uncertain significance |
| rs1443674587 | 10:98,923,152 | T/C | — | uncertain significance |
| rs149092674 | 10:98,924,593 | G/T | — | likely benign |
| rs1281679652 | 10:98,924,634 | T/A | — | uncertain significance |
| rs2784917 | 10:98,928,942 | A/G | intron variant | — |
| rs2636802 | 10:98,930,392 | T/C | regulatory region variant | — |
| rs2636797 | 10:98,931,738 | T/A | — | — |
| rs750436666 | 10:98,945,301 | G/T | — | uncertain significance |
| rs761078698 | 10:98,945,356 | C/G | — | uncertain significance |
| rs375276519 | 10:98,945,389 | G/A | — | uncertain significance |
| rs750406435 | 10:98,945,406 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.