SLX4

SLX4 structure-specific endonuclease subunit

Summary

This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia. [provided by RefSeq, Sep 2016]

Known Variants1,846 total

rsidPosition (GRCh37)AllelesClassClinVar
rs88605197216:3,631,193C/G—uncertain significance
rs11649826316:3,631,248C/T—benign
rs148569343816:3,631,296C/T—uncertain significance
rs11795859216:3,631,302T/C—likely benign
rs14963468216:3,631,308T/C—likely benign
rs7834649116:3,631,321T/C—benign
rs7577302716:3,631,339T/C—benign
rs5769939316:3,631,359G/A—benign
rs88605197316:3,631,386G/A—uncertain significance
rs103293695616:3,631,399T/C—uncertain significance
rs55772982216:3,631,456G/A—uncertain significance
rs57801199916:3,631,461G/A—uncertain significance
rs88605197416:3,631,472T/C—uncertain significance
rs37187950416:3,631,532C/G—uncertain significance
rs11569093716:3,631,536C/T—benign
rs7514681616:3,631,622A/G—benign
rs54141032916:3,631,685A/G—likely benign
rs11600372716:3,631,688C/T—benign
rs54691702616:3,631,691T/C—uncertain significance
rs78132253016:3,631,765C/T—uncertain significance
rs14616331016:3,631,788G/A—benign
rs53068189816:3,631,850C/A—uncertain significance
rs86827847016:3,631,874T/A—uncertain significance
rs36984353116:3,631,969G/A—uncertain significance
rs74966809516:3,632,032C/T—uncertain significance
rs88605197516:3,632,175A/C—uncertain significance
rs52884380716:3,632,215T/C—likely benign
rs7666133616:3,632,230G/A—benign
rs53141726316:3,632,241C/T—uncertain significance
rs55153859216:3,632,245T/C—conflicting classifications of pathogenicity
rs204044440116:3,632,261G/A—uncertain significance
rs146160825916:3,632,270C/T—uncertain significance
rs159651411816:3,632,289T/G—uncertain significance
rs375183916:3,632,335T/C—benign
rs55990384716:3,632,342A/G—uncertain significance
rs11173804216:3,632,347T/C—conflicting classifications of pathogenicity
rs75145675016:3,632,350C/T—uncertain significance
rs37510005016:3,632,351G/A—uncertain significance
rs204044711216:3,632,358C/T—likely benign
rs138395418916:3,632,365T/C—likely benign
rs215111540316:3,632,368C/A—uncertain significance
rs37355874116:3,632,371C/T—uncertain significance
rs19973678816:3,632,372G/A—uncertain significance
rs103747411416:3,632,378G/A—uncertain significance
rs37276732116:3,632,380C/T—uncertain significance
rs77123039516:3,632,381G/A—uncertain significance
rs147116043016:3,632,391C/T—likely benign
rs75034001916:3,632,402C/T—uncertain significance
rs19999857316:3,632,403C/T—likely benign
rs37588594116:3,632,404C/G—uncertain significance
rs20103676716:3,632,407C/T—uncertain significance
rs76772033616:3,632,408G/A—uncertain significance
rs20047381116:3,632,412G/A—likely benign
rs86718722816:3,632,414C/T—uncertain significance
rs14247756416:3,632,415G/A—likely benign
rs99981550916:3,632,421G/A—likely benign
rs37139010516:3,632,425A/C—uncertain significance
rs88605197616:3,632,430G/C—uncertain significance
rs74619112316:3,632,435A/G—uncertain significance
rs127097604716:3,632,436G/A—likely benign
rs77233238616:3,632,438G/A—uncertain significance
rs254820620516:3,632,439G/T—likely benign
rs215111554116:3,632,440G/A—uncertain significance
rs76043585916:3,632,444C/T—uncertain significance
rs57777011816:3,632,445C/G—likely benign
rs76953778916:3,632,459G/A—likely benign
rs77052969816:3,632,462T/C—uncertain significance
rs92670065816:3,632,464C/T—uncertain significance
rs76261920016:3,632,465G/A—uncertain significance
rs36884819116:3,632,466C/T—likely benign
rs77444273416:3,632,467G/A—uncertain significance
rs56038178616:3,632,476C/T—conflicting classifications of pathogenicity
rs37187509516:3,632,477G/A—uncertain significance
rs204044966016:3,632,480G/T—uncertain significance
rs37487662416:3,632,483C/T—uncertain significance
rs54298186416:3,632,484G/A—likely benign
rs125990992316:3,632,489G/C—uncertain significance
rs56249145016:3,632,494A/G—uncertain significance
rs133693131016:3,632,496C/T—likely benign
rs78026153216:3,632,512C/T—uncertain significance
rs215111566516:3,632,515A/C—uncertain significance
rs204045029716:3,632,520A/C—uncertain significance
rs74744281516:3,632,521A/C—uncertain significance
rs159651455916:3,632,523G/C—conflicting classifications of pathogenicity
rs76956787416:3,632,530T/C—uncertain significance
rs77305813316:3,632,532C/T—likely benign
rs254820637616:3,632,536A/G—uncertain significance
rs254820638016:3,632,539A/T—uncertain significance
rs77056950816:3,632,540C/T—uncertain significance
rs155544929716:3,632,544C/G—uncertain significance
rs204045081416:3,632,548T/C—uncertain significance
rs126586706916:3,632,550C/G—likely benign
rs36918007716:3,632,555C/T—uncertain significance
rs132444473516:3,632,556C/T—likely benign
rs103127441416:3,632,557G/A—uncertain significance
rs75941244716:3,632,559C/T—likely benign
rs14381882416:3,632,567G/A—benign
rs37764820116:3,632,570T/G—uncertain significance
rs76184522416:3,632,577C/T—likely benign
rs52744028716:3,632,583C/T—likely benign

Showing 100 of 1,846 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.