SNTG1

syntrophin gamma 1

Summary

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

Known Variants53 total

rsidPosition (GRCh37)AllelesClassClinVar
rs625153758:50,949,939C/G
rs2039148:51,015,441G/A
rs1911822638:51,024,225G/Aintron variant
rs2036208:51,028,100C/T
rs117789988:51,113,409A/Cintron variant
rs78247568:51,118,559T/Cintron variant
rs7645924578:51,306,814G/Auncertain significance
rs1425965728:51,314,798A/Cuncertain significance
rs353845688:51,314,818A/Clikely benign
rs1442836768:51,314,824C/Tuncertain significance
rs7771697788:51,314,825G/Auncertain significance
rs1477809328:51,314,877T/Guncertain significance
rs7652154558:51,351,126A/Glikely benign
rs1450936128:51,362,258G/Alikely benign
rs1389427178:51,363,116C/Tuncertain significance
rs14134796368:51,363,139A/Guncertain significance
rs1420728608:51,363,147T/Clikely benign
rs25360794388:51,363,248A/Tuncertain significance
rs1382628408:51,363,287G/Clikely benign
rs132722368:51,384,987A/Gintron variant
rs3105588:51,412,591C/Tintron variant
rs5287782718:51,415,359G/Auncertain significance
rs2009959708:51,415,377A/Guncertain significance
rs1418166788:51,415,396G/Cuncertain significance
rs25364144988:51,415,406T/Clikely benign
rs7653511758:51,442,763A/Guncertain significance
rs20942557238:51,442,793C/Tuncertain significance
rs7486237428:51,442,815A/Guncertain significance
rs7566472748:51,442,818C/Guncertain significance
rs340419458:51,449,321A/Gbenign
rs7795371688:51,449,328T/Guncertain significance
rs7467000968:51,449,330G/Clikely benign
rs1472000978:51,449,352G/Alikely benign
rs7546053848:51,465,626G/Tuncertain significance
rs1138056998:51,465,651C/Gbenign
rs21306085048:51,465,728A/Guncertain significance
rs1443504228:51,465,733G/Cuncertain significance
rs13038676138:51,569,476A/Guncertain significance
rs5286799578:51,569,546C/Tlikely benign
rs787261528:51,571,149A/Cbenign
rs3705101738:51,617,163A/Guncertain significance
rs1454545148:51,617,255C/Tlikely benign
rs2018314438:51,617,315G/Tlikely benign
rs757543848:51,620,467A/Gbenign
rs1996074798:51,621,494A/Guncertain significance
rs25375981768:51,621,516T/Cuncertain significance
rs1896822138:51,621,563G/Tbenign
rs3763620178:51,621,569T/Clikely benign
rs117761228:51,669,796A/C
rs109580998:51,673,736G/Adownstream gene variant
rs125473358:51,690,823C/G
rs25363125738:51,705,373C/Tuncertain significance
rs7749085908:51,705,393A/Glikely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.