SNX27

sorting nexin 27

Summary

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]

Known Variants339 total

rsidPosition (GRCh37)AllelesClassClinVar
rs21025780281:151,584,683G/T—likely benign
rs16672045351:151,584,691A/C—uncertain significance
rs13753196011:151,584,692C/G—uncertain significance
rs10271344761:151,584,693G/C—uncertain significance
rs9543082631:151,584,694G/A—uncertain significance
rs5511801491:151,584,695G/A—likely benign
rs21025781141:151,584,696G/A—uncertain significance
rs7661659591:151,584,704T/G—uncertain significance
rs16672058291:151,584,708C/T—uncertain significance
rs21025781771:151,584,710C/T—likely benign
rs7544741121:151,584,717C/T—uncertain significance
rs9653286861:151,584,718C/T—uncertain significance
rs25262319331:151,584,722C/G—uncertain significance
rs12443696821:151,584,726A/C—uncertain significance
rs10091935391:151,584,730G/C—uncertain significance
rs11811736781:151,584,733G/A—uncertain significance
rs25262321351:151,584,736G/T—uncertain significance
rs7523126031:151,584,746C/T—likely benign
rs10547367061:151,584,747G/T—uncertain significance
rs12937046811:151,584,749G/A—likely benign
rs15580282771:151,584,750G/T—uncertain significance
rs5712689321:151,584,751G/T—uncertain significance
rs7774997541:151,584,752G/A—likely benign
rs9484834731:151,584,758G/A—likely benign
rs13765981241:151,584,761C/T—likely benign
rs12442088681:151,584,764C/T—likely benign
rs16672112031:151,584,769C/T—uncertain significance
rs16672112901:151,584,770C/T—likely benign
rs16672116101:151,584,776C/T—likely benign
rs12363974301:151,584,780G/A—uncertain significance
rs7464339151:151,584,782C/T—likely benign
rs7803321221:151,584,787G/A—uncertain significance
rs13541587381:151,584,795G/A—uncertain significance
rs12527597171:151,584,797C/T—likely benign
rs11959116001:151,584,806C/T—likely benign
rs7471086731:151,584,807G/C—uncertain significance
rs7769203171:151,584,815C/T—likely benign
rs16672148451:151,584,816G/A—uncertain significance
rs7626002911:151,584,818C/T—likely benign
rs15717414491:151,584,824C/T—likely benign
rs16672159751:151,584,837G/A—uncertain significance
rs25262336041:151,584,851G/C—likely benign
rs21025788361:151,584,856A/C—uncertain significance
rs7595070121:151,584,866G/A—likely benign
rs10025104801:151,584,875A/G—likely benign
rs3752136751:151,584,876C/T—likely benign
rs12252014751:151,584,888A/G—uncertain significance
rs13416443651:151,584,890C/G—uncertain significance
rs11982373091:151,584,894G/A—uncertain significance
rs10366856651:151,584,896G/A—likely benign
rs7602637261:151,584,908G/A—likely benign
rs16672185701:151,584,909C/T—likely benign
rs7635859791:151,584,911G/A—likely benign
rs15717416011:151,584,915C/G—uncertain significance
rs7535406431:151,584,916A/T—uncertain significance
rs5337240491:151,584,917T/C—likely benign
rs7793780551:151,584,926C/T—likely benign
rs14151468701:151,584,929G/C—likely benign
rs7509449111:151,584,936G/T—uncertain significance
rs13840335301:151,584,937G/C—uncertain significance
rs13804555511:151,584,938G/T—likely benign
rs12318125521:151,584,940G/C—uncertain significance
rs3690179511:151,584,941G/T—likely benign
rs7470227801:151,584,948G/T—uncertain significance
rs7687980771:151,584,952G/T—uncertain significance
rs21025792031:151,584,956C/A—likely benign
rs16672222761:151,584,969G/A—uncertain significance
rs21025792461:151,584,975C/A—uncertain significance
rs25262352781:151,584,981C/T—likely benign
rs21025792711:151,584,983G/C—likely benign
rs21025792941:151,584,997C/T—likely benign
rs25262353951:151,584,999G/A—likely benign
rs25262354061:151,585,001G/A—likely benign
rs25262354381:151,585,003T/G—likely benign
rs14002480221:151,585,008G/A—likely benign
rs5296741921:151,610,326C/G——
rs21026329091:151,611,348C/G—likely benign
rs12775533041:151,611,350C/G—likely benign
rs16685913771:151,611,355T/C—likely benign
rs16685920051:151,611,369A/C—uncertain significance
rs5748755061:151,611,370C/T—likely benign
rs10042585891:151,611,375A/G—uncertain significance
rs5679182351:151,611,388G/C—likely benign
rs7779980611:151,611,394C/T—likely benign
rs3714397071:151,611,397G/A—likely benign
rs7718661941:151,611,399A/G—uncertain significance
rs7753918771:151,611,403G/C—likely benign
rs7761591141:151,611,412G/C—likely benign
rs21026330731:151,611,416C/A—likely benign
rs25248848191:151,611,421A/G—likely benign
rs7679296161:151,611,440T/A—uncertain significance
rs7561866231:151,611,448G/C—likely benign
rs21026331551:151,611,451A/G—likely benign
rs7495691611:151,611,458C/T—uncertain significance
rs13001830811:151,611,474A/T—uncertain significance
rs7798631001:151,611,475T/C—likely benign
rs7476364721:151,611,489G/C—uncertain significance
rs7694917471:151,611,493C/T—likely benign
rs7632303411:151,611,498C/T—uncertain significance
rs7645877701:151,611,499G/A—likely benign

Showing 100 of 339 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.