SOAT1

sterol O-acyltransferase 1

Summary

The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Known Variants42 total

rsidPosition (GRCh37)AllelesClassClinVar
rs22470611:179,269,079G/Aintron variant
rs7751510881:179,271,837G/Tuncertain significance
rs7631884251:179,271,844C/Guncertain significance
rs25276694091:179,271,904C/Tuncertain significance
rs1445397571:179,271,916T/Auncertain significance
rs1504121611:179,271,924G/Alikely benign
rs22504771:179,274,897G/Cregulatory region variant
rs75234311:179,278,005A/C
rs46523641:179,283,843C/G
rs24844461:179,290,195C/Tintron variant
rs5569361191:179,292,608T/Cuncertain significance
rs1435876811:179,293,438A/Gintron variant
rs618243681:179,298,809C/Tintron variant
rs21249830571:179,304,774A/Guncertain significance
rs11788724221:179,306,994C/Auncertain significance
rs7604434081:179,308,662A/Guncertain significance
rs3702648061:179,310,215G/Auncertain significance
rs3766268621:179,310,221T/Guncertain significance
rs751024841:179,310,244G/Abenign
rs2014336821:179,310,246C/Guncertain significance
rs115765171:179,310,262C/Gsynonymous variant
rs730486131:179,310,275C/Gbenign
rs782182361:179,310,313G/Abenign
rs2008546671:179,310,320C/Tuncertain significance
rs16663589071:179,311,262T/Cuncertain significance
rs7500938371:179,311,304T/Cuncertain significance
rs1442557851:179,311,323A/Gbenign
rs1433532031:179,311,325C/Tuncertain significance
rs14708751891:179,312,014A/Guncertain significance
rs133067281:179,312,559A/Gintron variant
rs3767071481:179,312,756A/Guncertain significance
rs25278104821:179,314,123G/Cuncertain significance
rs25278218701:179,316,741T/Cuncertain significance
rs25278222211:179,316,798A/Tuncertain significance
rs25278264301:179,318,012T/Guncertain significance
rs3716793601:179,319,482T/Cuncertain significance
rs1491898121:179,319,488G/Auncertain significance
rs37535261:179,319,541C/Gsynonymous variant
rs133067311:179,320,578A/Gmissense variant
rs1511123431:179,322,763G/Auncertain significance
rs7711854531:179,322,768G/Auncertain significance
rs10449251:179,323,738C/T

Gene information from NCBI Gene. Variant classifications from ClinVar.