SRGAP1

SLIT-ROBO Rho GTPase activating protein 1

Summary

The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]

Known Variants86 total

rsidPosition (GRCh37)AllelesClassClinVar
rs5626418212:64,238,097A/Gregulatory region variant—
rs75259687512:64,238,672G/A—likely benign
rs57031426712:64,297,800C/G——
rs1242291812:64,312,610G/Tregulatory region variant—
rs14240916912:64,377,804C/T—likely benign
rs148342270812:64,377,820G/A—uncertain significance
rs77817449912:64,377,841C/T—uncertain significance
rs36883997212:64,377,842G/A—likely benign
rs250100300912:64,377,866G/C—uncertain significance
rs20172040012:64,377,881C/A—uncertain significance
rs75566815812:64,410,726A/T—likely benign
rs78162618712:64,410,750A/Cmissense variantuncertain significance
rs143083069012:64,410,755A/T—uncertain significance
rs77100110212:64,410,791C/T—uncertain significance
rs658153112:64,435,179T/G——
rs75709930112:64,436,635C/T—likely benign
rs20107553112:64,436,711C/T—uncertain significance
rs14247772112:64,437,223C/G—benign
rs13833803712:64,437,273G/A—uncertain significance
rs249896422012:64,437,314G/A—uncertain significance
rs120807497512:64,456,701G/A—uncertain significance
rs79704499012:64,456,718G/Amissense variantpathogenic
rs76944005412:64,456,746A/G—uncertain significance
rs76887394912:64,456,835G/A—uncertain significance
rs1182964912:64,456,947G/A—benign
rs11290857012:64,458,987C/T—benign
rs20117736612:64,472,691A/G—likely benign
rs6175619012:64,472,710G/A—benign
rs37564294612:64,472,711A/T—uncertain significance
rs213656215012:64,472,737A/C—uncertain significance
rs75121021412:64,472,790G/A—uncertain significance
rs77345169412:64,472,902C/T—likely benign
rs20117074212:64,485,095G/A—likely benign
rs14918045112:64,485,115A/G—uncertain significance
rs104911434112:64,485,152C/T—likely benign
rs37313702912:64,488,702C/T—benign
rs77441502212:64,488,964T/C—uncertain significance
rs11534352912:64,491,047A/G—likely benign
rs19987178612:64,491,076C/G—likely benign
rs96928833212:64,491,086C/T—uncertain significance
rs11481781712:64,502,747C/T—risk factor
rs20140437912:64,502,748G/A—uncertain significance
rs213661230112:64,502,767G/T—uncertain significance
rs100542330312:64,502,804G/T—uncertain significance
rs37022903112:64,502,825C/T—likely benign
rs159233212512:64,505,615C/A—uncertain significance
rs125238476512:64,505,685T/C—uncertain significance
rs146184058812:64,505,699A/G—uncertain significance
rs77264017012:64,505,733T/G—uncertain significance
rs76353287612:64,505,746T/C—likely benign
rs57767925512:64,509,595G/A—uncertain significance
rs37555987612:64,519,750G/A—likely benign
rs144612441612:64,519,811G/A—uncertain significance
rs14109794312:64,519,836C/T—benign
rs1230306012:64,519,890C/T—benign
rs76605684712:64,519,899C/T—likely benign
rs11556470112:64,521,379G/A—benign
rs76264339412:64,521,455A/G—uncertain significance
rs77073524112:64,521,467T/C—uncertain significance
rs37244146612:64,521,479C/G—uncertain significance
rs203671729512:64,521,501C/T—uncertain significance
rs249918894212:64,521,651A/G—uncertain significance
rs148520755112:64,521,662A/G—likely benign
rs74872318112:64,521,666C/G—uncertain significance
rs77655028612:64,521,700G/T—uncertain significance
rs6175422112:64,521,724G/A—benign
rs76809195612:64,521,798C/G—uncertain significance
rs37322745712:64,521,831C/T—uncertain significance
rs57203042112:64,521,834A/G—uncertain significance
rs77915425212:64,521,851C/G—uncertain significance
rs37760176112:64,521,868G/A—uncertain significance
rs5866933612:64,521,872C/T—benign
rs36923130112:64,521,890C/T—likely benign
rs77590637312:64,521,925G/A—uncertain significance
rs76414710612:64,521,934C/T—uncertain significance
rs75564272212:64,521,947C/A—uncertain significance
rs11330223112:64,521,957C/G—benign
rs54986633412:64,536,211C/T—uncertain significance
rs13929690812:64,536,236C/T—likely benign
rs78104270512:64,536,271G/A—uncertain significance
rs11523761512:64,536,277C/T—uncertain significance
rs3470604112:64,536,278G/A—benign
rs14513856412:64,536,301G/A—uncertain significance
rs139888904512:64,536,315A/G—uncertain significance
rs138763256212:64,536,427C/T—uncertain significance
rs91475842012:64,536,434C/G—uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.