SULF2
sulfatase 2
Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Known Variants78 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2281279 | 20:46,290,250 | T/C | downstream gene variant | — |
| rs533810544 | 20:46,290,537 | C/T | — | uncertain significance |
| rs551763867 | 20:46,290,589 | C/T | — | uncertain significance |
| rs1319684839 | 20:46,290,599 | G/T | — | uncertain significance |
| rs1602578892 | 20:46,291,824 | T/C | — | uncertain significance |
| rs964003583 | 20:46,291,837 | C/T | — | uncertain significance |
| rs145371797 | 20:46,291,893 | T/C | — | uncertain significance |
| rs149155853 | 20:46,291,906 | T/G | — | uncertain significance |
| rs2520173779 | 20:46,291,935 | G/T | — | uncertain significance |
| rs773041924 | 20:46,292,200 | T/A | — | uncertain significance |
| rs759894834 | 20:46,292,210 | C/T | — | likely benign |
| rs768084550 | 20:46,292,211 | G/A | — | uncertain significance |
| rs1177481235 | 20:46,292,218 | G/T | — | uncertain significance |
| rs145659660 | 20:46,292,361 | C/T | — | likely benign |
| rs10048853 | 20:46,292,910 | C/T | — | benign |
| rs763909307 | 20:46,292,915 | T/A | — | uncertain significance |
| rs1265172350 | 20:46,292,926 | T/C | — | likely benign |
| rs1253732761 | 20:46,292,931 | T/C | — | uncertain significance |
| rs1213281371 | 20:46,293,944 | T/C | — | uncertain significance |
| rs373243624 | 20:46,293,994 | C/T | — | uncertain significance |
| rs755234583 | 20:46,294,603 | C/T | — | uncertain significance |
| rs567938432 | 20:46,294,683 | T/A | — | uncertain significance |
| rs73624692 | 20:46,295,000 | T/C | — | benign |
| rs763644883 | 20:46,295,029 | C/T | — | uncertain significance |
| rs753597018 | 20:46,295,030 | G/A | — | likely benign |
| rs780583306 | 20:46,295,041 | C/T | — | uncertain significance |
| rs200804767 | 20:46,295,158 | C/T | — | uncertain significance |
| rs755453376 | 20:46,295,173 | C/T | — | uncertain significance |
| rs115495231 | 20:46,295,174 | G/A | — | benign |
| rs373298444 | 20:46,300,949 | G/C | — | uncertain significance |
| rs1444096755 | 20:46,300,956 | T/C | — | uncertain significance |
| rs200396483 | 20:46,300,962 | C/T | — | uncertain significance |
| rs374099915 | 20:46,300,963 | G/A | — | uncertain significance |
| rs149787530 | 20:46,301,026 | C/T | — | uncertain significance |
| rs575139977 | 20:46,301,065 | C/T | — | likely benign |
| rs2520277062 | 20:46,301,089 | A/G | — | uncertain significance |
| rs1347690937 | 20:46,301,093 | A/C | — | uncertain significance |
| rs368203432 | 20:46,301,094 | T/C | — | uncertain significance |
| rs1202070923 | 20:46,305,242 | C/G | — | uncertain significance |
| rs762937870 | 20:46,305,259 | C/T | — | likely benign |
| rs141076850 | 20:46,305,296 | C/T | — | uncertain significance |
| rs1046641831 | 20:46,305,847 | G/A | — | uncertain significance |
| rs752328407 | 20:46,305,861 | T/A | — | uncertain significance |
| rs34107769 | 20:46,306,828 | T/A | coding sequence variant | — |
| rs555983051 | 20:46,307,438 | G/A | — | uncertain significance |
| rs373491304 | 20:46,311,769 | C/T | — | uncertain significance |
| rs779478106 | 20:46,311,866 | G/C | — | uncertain significance |
| rs769361738 | 20:46,311,878 | G/C | — | uncertain significance |
| rs772766001 | 20:46,311,880 | C/T | — | uncertain significance |
| rs115179010 | 20:46,313,190 | G/A | — | benign |
| rs142401598 | 20:46,318,883 | C/T | — | uncertain significance |
| rs368790693 | 20:46,318,897 | C/T | — | uncertain significance |
| rs753117627 | 20:46,318,898 | G/A | — | uncertain significance |
| rs139603157 | 20:46,318,953 | C/T | — | uncertain significance |
| rs2088149680 | 20:46,318,961 | C/T | — | uncertain significance |
| rs188934676 | 20:46,318,977 | C/T | — | uncertain significance |
| rs1296283324 | 20:46,318,978 | A/G | — | uncertain significance |
| rs200775510 | 20:46,319,014 | T/C | — | uncertain significance |
| rs61730619 | 20:46,331,275 | G/A | — | likely benign |
| rs143543334 | 20:46,331,280 | C/T | — | uncertain significance |
| rs562017382 | 20:46,365,452 | C/T | — | uncertain significance |
| rs774832820 | 20:46,365,477 | C/T | — | uncertain significance |
| rs754933809 | 20:46,365,521 | G/A | — | uncertain significance |
| rs2521891097 | 20:46,365,539 | G/T | — | uncertain significance |
| rs564524993 | 20:46,365,561 | C/T | — | uncertain significance |
| rs991673061 | 20:46,365,587 | C/A | — | uncertain significance |
| rs1325241816 | 20:46,365,670 | C/T | — | uncertain significance |
| rs1029474868 | 20:46,385,980 | C/T | — | uncertain significance |
| rs776772374 | 20:46,385,992 | C/A | — | uncertain significance |
| rs761826256 | 20:46,385,993 | G/A | — | uncertain significance |
| rs764885914 | 20:46,386,019 | C/T | — | uncertain significance |
| rs200007986 | 20:46,386,028 | G/A | — | uncertain significance |
| rs138931945 | 20:46,386,040 | G/A | — | uncertain significance |
| rs192483319 | 20:46,386,089 | C/T | — | likely benign |
| rs6018677 | 20:46,392,065 | A/G | intron variant | — |
| rs4810685 | 20:46,400,713 | T/A | — | — |
| rs111783138 | 20:46,413,137 | A/G | intron variant | — |
| rs113305091 | 20:46,413,163 | C/T | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.