SUN2
Sad1 and UNC84 domain containing 2
Summary
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Known Variants402 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs917841252 | 22:39,132,275 | G/T | — | uncertain significance |
| rs2517922238 | 22:39,132,279 | G/T | — | uncertain significance |
| rs199842876 | 22:39,132,281 | G/A | — | likely benign |
| rs2092804001 | 22:39,132,286 | C/T | — | uncertain significance |
| rs2517922595 | 22:39,132,304 | G/A | — | uncertain significance |
| rs377445434 | 22:39,132,312 | C/G | — | uncertain significance |
| rs781099795 | 22:39,132,322 | C/G | — | uncertain significance |
| rs748074497 | 22:39,132,323 | G/A | — | likely benign |
| rs535964776 | 22:39,132,332 | C/G | — | uncertain significance |
| rs137996727 | 22:39,132,348 | C/T | — | uncertain significance |
| rs370298150 | 22:39,132,349 | G/A | — | uncertain significance |
| rs1603210228 | 22:39,132,352 | G/A | — | likely benign |
| rs2517923162 | 22:39,132,353 | C/G | — | uncertain significance |
| rs140261344 | 22:39,132,368 | C/T | — | likely benign |
| rs150292176 | 22:39,132,369 | G/A | — | uncertain significance |
| rs375420471 | 22:39,132,378 | G/A | — | uncertain significance |
| rs751159582 | 22:39,132,383 | G/T | — | likely benign |
| rs559096453 | 22:39,132,385 | C/T | — | uncertain significance |
| rs748508144 | 22:39,132,401 | A/G | — | likely benign |
| rs138702 | 22:39,132,601 | A/T | — | benign |
| rs2517948050 | 22:39,134,159 | G/C | — | likely benign |
| rs781734474 | 22:39,134,173 | C/T | — | uncertain significance |
| rs372381106 | 22:39,134,174 | G/A | — | uncertain significance |
| rs1486287848 | 22:39,134,179 | T/C | — | uncertain significance |
| rs539775471 | 22:39,134,184 | G/A | — | likely benign |
| rs771616583 | 22:39,134,186 | G/A | — | uncertain significance |
| rs775107257 | 22:39,134,190 | C/T | — | likely benign |
| rs367828475 | 22:39,134,201 | G/T | — | uncertain significance |
| rs2092823875 | 22:39,134,205 | G/A | — | uncertain significance |
| rs549404842 | 22:39,134,216 | C/T | — | uncertain significance |
| rs146141522 | 22:39,134,217 | G/A | — | benign |
| rs755259603 | 22:39,134,221 | G/A | — | uncertain significance |
| rs1285036282 | 22:39,134,228 | T/G | — | uncertain significance |
| rs781644199 | 22:39,134,234 | G/T | — | uncertain significance |
| rs2517949866 | 22:39,134,246 | C/T | — | uncertain significance |
| rs749813392 | 22:39,134,261 | C/T | — | uncertain significance |
| rs768318554 | 22:39,134,283 | C/T | — | likely benign |
| rs1569294585 | 22:39,134,585 | T/C | — | likely benign |
| rs1216450168 | 22:39,134,597 | T/C | — | likely benign |
| rs2517957059 | 22:39,134,599 | G/A | — | uncertain significance |
| rs2092827661 | 22:39,134,618 | T/A | — | uncertain significance |
| rs779490476 | 22:39,134,619 | G/A | — | likely benign |
| rs112637685 | 22:39,134,643 | G/A | — | benign |
| rs1021027363 | 22:39,134,645 | C/T | — | uncertain significance |
| rs2092828049 | 22:39,134,653 | A/G | — | uncertain significance |
| rs769627673 | 22:39,134,660 | C/G | — | uncertain significance |
| rs772891603 | 22:39,134,669 | C/T | — | uncertain significance |
| rs762930089 | 22:39,134,670 | G/A | — | likely benign |
| rs566312173 | 22:39,134,680 | C/T | — | uncertain significance |
| rs141013997 | 22:39,134,681 | G/A | — | likely benign |
| rs757720826 | 22:39,134,698 | C/T | — | uncertain significance |
| rs182710324 | 22:39,134,699 | G/A | — | uncertain significance |
| rs2517958481 | 22:39,134,701 | A/G | — | uncertain significance |
| rs754499171 | 22:39,134,708 | C/T | — | uncertain significance |
| rs780635160 | 22:39,134,709 | G/A | — | likely benign |
| rs949979981 | 22:39,134,713 | C/G | — | uncertain significance |
| rs1062687 | 22:39,134,715 | C/T | — | benign |
| rs1384723835 | 22:39,134,732 | C/T | — | uncertain significance |
| rs749129041 | 22:39,134,742 | G/A | — | likely benign |
| rs770892695 | 22:39,134,754 | A/T | — | uncertain significance |
| rs749003532 | 22:39,134,861 | G/T | — | likely benign |
| rs374667255 | 22:39,134,871 | T/A | — | likely benign |
| rs1446967356 | 22:39,134,891 | C/T | — | uncertain significance |
| rs775697034 | 22:39,134,892 | G/A | — | uncertain significance |
| rs1370457089 | 22:39,134,911 | C/A | — | uncertain significance |
| rs570193292 | 22:39,134,917 | G/A | — | benign |
| rs537241816 | 22:39,134,923 | G/T | — | likely benign |
| rs750800615 | 22:39,134,925 | C/T | — | uncertain significance |
| rs369397415 | 22:39,134,941 | G/A | — | likely benign |
| rs766829876 | 22:39,134,944 | C/T | — | likely benign |
| rs752150588 | 22:39,134,945 | G/A | — | uncertain significance |
| rs868474704 | 22:39,134,955 | C/T | — | uncertain significance |
| rs8138622 | 22:39,134,956 | G/A | — | likely benign |
| rs1352285124 | 22:39,134,966 | G/C | — | uncertain significance |
| rs1370359939 | 22:39,134,973 | G/A | — | uncertain significance |
| rs1318955450 | 22:39,134,980 | G/A | — | likely benign |
| rs371141749 | 22:39,134,985 | C/T | — | uncertain significance |
| rs150014549 | 22:39,134,986 | G/A | — | likely benign |
| rs1045388817 | 22:39,135,001 | A/G | — | likely benign |
| rs1253907495 | 22:39,135,004 | A/G | — | likely benign |
| rs747023868 | 22:39,135,011 | G/A | — | likely benign |
| rs372134058 | 22:39,135,337 | G/C | — | likely benign |
| rs373767572 | 22:39,135,342 | C/T | — | uncertain significance |
| rs367645117 | 22:39,135,343 | G/A | — | uncertain significance |
| rs2092834834 | 22:39,135,362 | C/T | — | uncertain significance |
| rs140661422 | 22:39,135,363 | G/A | — | likely benign |
| rs758076166 | 22:39,135,377 | C/T | — | uncertain significance |
| rs754873310 | 22:39,135,383 | G/A | — | uncertain significance |
| rs539760038 | 22:39,135,397 | C/T | — | uncertain significance |
| rs2092835149 | 22:39,135,398 | G/A | — | uncertain significance |
| rs777909776 | 22:39,135,417 | G/A | — | likely benign |
| rs149140279 | 22:39,135,419 | T/C | — | benign |
| rs2517972296 | 22:39,135,425 | G/A | — | uncertain significance |
| rs2517972426 | 22:39,135,431 | G/C | — | uncertain significance |
| rs1452088970 | 22:39,135,447 | C/T | — | uncertain significance |
| rs77470650 | 22:39,135,699 | T/C | — | benign |
| rs2517978037 | 22:39,135,743 | A/G | — | uncertain significance |
| rs1417867039 | 22:39,135,752 | T/C | — | uncertain significance |
| rs144975270 | 22:39,135,763 | C/T | — | likely benign |
| rs567532014 | 22:39,135,764 | G/A | — | likely benign |
Showing 100 of 402 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.