Trait
SNPs associated with Hypothyroidism
1197 genetic variants across 284 genes have been associated with Hypothyroidism in published research. Key genes include ABO, ADCY7, AGO2.
Associated variants1,197 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs6679677 | PHTF1 | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs925489 | PTCSC2 | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs7030256 | PTCSC2 | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs7847663 | PTCSC2 | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs75778624 | VAV3 | GWAS association (p=6.0e-322) | Major Consortium Study |
| rs3184504 | SH2B3 | GWAS association (p=3.0e-268) | Major Consortium Study |
| rs11675342 | — | GWAS association (p=2.0e-231) | Major Consortium Study |
| rs3087243 | CTLA4 | GWAS association (p=7.0e-208) | Major Consortium Study |
| rs2476601 | PTPN22 | GWAS association (p=3.0e-198) | Major Consortium Study |
| rs1479567 | PDE8B | GWAS association (p=3.0e-181) | Major Consortium Study |
| rs1203925 | LNCNEF | GWAS association (p=5.0e-143) | Major Consortium Study |
| rs3134996 | — | GWAS association (p=5.0e-139) | Major Consortium Study |
| rs17025017 | — | GWAS association (p=4.0e-134) | Major Consortium Study |
| rs995734 | LNCNEF | GWAS association (p=2.0e-121) | Major Consortium Study |
| rs17020127 | — | GWAS association (p=8.0e-108) | Major Consortium Study |
| rs11211645 | — | GWAS association (p=6.0e-98) | Major Consortium Study |
| rs11052877 | — | GWAS association (p=7.0e-92) | Major Consortium Study |
| rs7310615 | SH2B3 | GWAS association (p=1.0e-83) | Major Consortium Study |
| rs1007458 | LNCNEF | GWAS association (p=4.0e-78) | Major Consortium Study |
| rs1203923 | — | GWAS association (p=5.0e-77) | Major Consortium Study |
| rs7565213 | — | GWAS association (p=1.0e-76) | Major Consortium Study |
| rs7754251 | — | GWAS association (p=1.0e-75) | Major Consortium Study |
| rs310753 | SYN2 | GWAS association (p=3.0e-71) | Major Consortium Study |
| rs76428106 | — | GWAS association (p=2.0e-65) | Major Consortium Study |
| rs1534424 | — | GWAS association (p=1.0e-59) | Major Consortium Study |
| rs229527 | C1QTNF6 | GWAS association (p=1.0e-53) | Major Consortium Study |
| rs10425559 | — | GWAS association (p=5.0e-52) | Major Consortium Study |
| rs3775291 | TLR3 | GWAS association (p=8.0e-51) | Major Consortium Study |
| rs10748781 | — | GWAS association (p=7.0e-49) | Major Consortium Study |
| rs2921053 | — | GWAS association (p=2.0e-45) | Major Consortium Study |
| rs17767491 | — | GWAS association (p=5.0e-43) | Major Consortium Study |
| rs12149203 | LOC105371356 | GWAS association (p=1.0e-42) | Major Consortium Study |
| rs10814915 | — | GWAS association (p=1.0e-41) | Major Consortium Study |
| rs2479431 | — | GWAS association (p=4.0e-39) | Major Consortium Study |
| rs2696423 | LRRC37A | GWAS association (p=1.0e-36) | Major Consortium Study |
| rs2148080 | RAB20 | GWAS association (p=3.0e-36) | Major Consortium Study |
| rs9291444 | — | GWAS association (p=3.0e-36) | Major Consortium Study |
| rs11757605 | CASC15 | GWAS association (p=4.0e-36) | Major Consortium Study |
| rs2256672 | — | GWAS association (p=9.0e-36) | Major Consortium Study |
| rs13020935 | — | GWAS association (p=1.0e-35) | Major Consortium Study |
| rs10028213 | LOC107986195 | GWAS association (p=5.0e-35) | Major Consortium Study |
| rs62291440 | LPP | GWAS association (p=6.0e-35) | Major Consortium Study |
| rs9828967 | — | GWAS association (p=9.0e-35) | Major Consortium Study |
| rs2456451 | — | GWAS association (p=4.0e-34) | Major Consortium Study |
| rs9851967 | LPP | GWAS association (p=9.0e-34) | Major Consortium Study |
| rs35006079 | CASC19 | GWAS association (p=1.0e-27) | Major Consortium Study |
| rs12113982 | — | GWAS association (p=2.0e-27) | Major Consortium Study |
| rs2696422 | LRRC37A | GWAS association (p=4.0e-27) | Major Consortium Study |
| rs151213404 | RNASET2 | GWAS association (p=6.0e-27) | Major Consortium Study |
| rs2016105 | — | GWAS association (p=2.0e-26) | Major Consortium Study |
| rs1024255 | NEK6 | GWAS association (p=4.0e-26) | Major Consortium Study |
| rs310758 | — | GWAS association (p=9.0e-26) | Major Consortium Study |
| rs16799 | MIR3681HG | GWAS association (p=2.0e-22) | Major Consortium Study |
| rs4690362 | — | GWAS association (p=2.0e-22) | Major Consortium Study |
| rs965513 | PTCSC2 | GWAS association (p=4.0e-22) | Major Consortium Study |
| rs706778 | IL2RA | GWAS association (p=1.0e-21) | Major Consortium Study |
| rs13290258 | PTCSC2 | GWAS association (p=6.0e-20) | Major Consortium Study |
| rs4983539 | — | GWAS association (p=3.0e-19) | Major Consortium Study |
| rs912353 | — | GWAS association (p=3.0e-19) | Major Consortium Study |
| rs4983386 | — | GWAS association (p=3.0e-19) | Major Consortium Study |
| rs6780171 | IGF2BP2 | GWAS association (p=6.0e-19) | Major Consortium Study |
| rs3892354 | — | GWAS association (p=2.0e-18) | Major Consortium Study |
| rs7254729 | — | GWAS association (p=2.0e-17) | Major Consortium Study |
| rs4341129 | NRG1 | GWAS association (p=2.0e-17) | Major Consortium Study |
| rs4853458 | STAT4 | GWAS association (p=7.0e-17) | Major Consortium Study |
| rs17364832 | — | GWAS association (p=7.0e-17) | Major Consortium Study |
| rs8179673 | STAT4 | GWAS association (p=1.0e-16) | Major Consortium Study |
| rs2640564 | — | GWAS association (p=3.0e-16) | Major Consortium Study |
| rs34376504 | LOC107986913 | GWAS association (p=4.0e-16) | Major Consortium Study |
| rs12056746 | NRG1 | GWAS association (p=7.0e-16) | Major Consortium Study |
| rs7327979 | SPATA13 | GWAS association (p=8.0e-16) | Major Consortium Study |
| rs2210913 | FCRL3 | GWAS association (p=1.0e-15) | Major Consortium Study |
| rs2412975 | HORMAD2 | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs1742869 | LOC105370452 | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs945635 | FCRL3 | GWAS association (p=6.0e-15) | Major Consortium Study |
| rs61938962 | — | GWAS association (p=8.0e-15) | Major Consortium Study |
| rs10836364 | — | GWAS association (p=9.0e-15) | Major Consortium Study |
| rs2412971 | HORMAD2 | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs9272293 | HLA-DQA1 | GWAS association (p=5.0e-14) | Major Consortium Study |
| rs7566688 | THAP4 | GWAS association (p=5.0e-14) | Major Consortium Study |
| rs59381142 | — | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs6414219 | THAP4 | GWAS association (p=1.0e-13) | Major Consortium Study |
| rs4578973 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs3761959 | FCRL3 | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs73398276 | FAM227B | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs1978594 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs6955503 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs660637 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs527767731 | SMC6 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs2654188 | — | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs55896290 | — | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs7248104 | INSR | GWAS association (p=1.0e-75) | Major Consortium Study |
| rs71508903 | ARID5B | GWAS association (p=9.0e-80) | Major Consortium Study |
| rs4409785 | — | GWAS association (p=5.0e-78) | Major Consortium Study |
| rs1079418 | PDE10A | GWAS association (p=2.0e-59) | Major Consortium Study |
| rs7090530 | — | GWAS association (p=1.0e-56) | Major Consortium Study |
| rs1050979 | — | GWAS association (p=6.0e-46) | Major Consortium Study |
| rs10844706 | CD69 | GWAS association (p=8.0e-23) | Major Consortium Study |
| rs116909374 | LOC124903302 | GWAS association (p=6.0e-51) | Major Consortium Study |
| rs121912648 | TG | GWAS association (p=9.0e-39) | Major Consortium Study |
Showing the top 100 of 1,197 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.