rs925489
This variant is located in the PTCSC2 gene.
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hypothyroidism
White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele T
OR 0.25
p —
N 2,444,128
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.21
p 3.0e-24
N 626,175
Major Consortium StudyLarge GWAS
multi-ancestry
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.20
p 4.0e-92
N 394,626
Large GWAS
European
Eriksson N et al. “Novel associations for hypothyroidism include known autoimmune risk loci.” Plos One 7(4):e34442 (2012)
Allele T
OR 1.28
p 2.0e-19
N 39,282
Large GWAS
European
autoimmune thyroid disease
Saevarsdottir S et al. “FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.” Nature 584(7822):619-623 (2020)
Allele T
OR 1.25
p 9.0e-110
N 754,406
Large GWAS
European
Zeng Y et al. “Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.” The American Journal of Psychiatry 180(4):294-304 (2023)
Allele T
OR 0.82
p 7.0e-77
N 376,871
Large GWAS
European
thyroid carcinoma
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.56
p 9.0e-35
N 670,697
Large GWAS
multi-ancestry
Thyroid stimulating hormone level
Zhan M et al. “Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.” Human Molecular Genetics 23(20):5505-17 (2014)
Allele C
OR —
β 0.058
p 1.0e-13
N 1,346
Large GWAS
East Asian
thyroid cancer
Zhou W et al. “Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.” Nature Genetics 50(9):1335-1341 (2018)
Allele T
OR —
p 5.0e-11
N 407,757
Large GWAS
European
atrial fibrillation
Roselli C et al. “Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.” Nature Genetics 57(3):539-547 (2025)
Allele C
OR 1.03
p 2.0e-10
N 1,650,345
Meta-analysisLarge GWAS
multi-ancestry
nodular goiter
White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele T
OR 0.12
p 5.0e-9
N 208,341
Large GWAS
African unspecified
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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