Trait
SNPs associated with Thyroid cancer
25 genetic variants across 13 genes have been associated with Thyroid cancer in published research. Key genes include CASC8, CHEK2, DIRC3.
Associated variants25 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs16857609 | DIRC3 | GWAS association (p=1.0e-57) | Meta-analysis |
| rs3802160 | NRG1 | GWAS association (p=2.0e-40) | Meta-analysis |
| rs116909374 | LOC124903302 | GWAS association (p=5.0e-32) | Meta-analysis |
| rs73227498 | EPB41L4A | GWAS association (p=1.0e-18) | Meta-analysis |
| rs7734992 | TERT | GWAS association (p=4.0e-17) | Meta-analysis |
| rs9971770 | — | GWAS association (p=3.0e-16) | Meta-analysis |
| rs12130559 | — | GWAS association (p=2.0e-10) | Meta-analysis |
| rs139566210 | — | GWAS association (p=3.0e-10) | Meta-analysis |
| rs944289 | NKX2-1 | Increased papillary thyroid cancer risk | Meta-analysis |
| rs17767904 | — | GWAS association (p=6.0e-09) | Meta-analysis |
| rs6983267 | CASC8 | Higher thyroid cancer risk | Meta-analysis |
| rs13290258 | PTCSC2 | GWAS association (p=1.0e-47) | Major Consortium Study |
| rs7726159 | TERT | Increased thyroid cancer risk | Major Consortium Study |
| rs8020481 | LINC00609 | GWAS association (p=6.0e-21) | Major Consortium Study |
| rs57481445 | DIRC3 | GWAS association (p=9.0e-21) | Major Consortium Study |
| rs9642727 | NRG1 | GWAS association (p=4.0e-17) | Major Consortium Study |
| rs369713868 | — | GWAS association (p=8.0e-13) | Major Consortium Study |
| rs537876632 | ZNF765 | GWAS association (p=6.0e-12) | Major Consortium Study |
| rs10786774 | STN1 | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs142700723 | — | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs191643749 | — | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs17879961 | CHEK2 | Increased thyroid cancer risk | Large GWAS |
| rs925489 | PTCSC2 | GWAS association (p=5.0e-11) | Large GWAS |
| rs149128637 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs2145418 | SPAG17 | Higher thyroid cancer risk | Candidate gene study |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.