AGO2

argonaute RISC catalytic component 2

Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Known Variants108 total

rsidPosition (GRCh37)AllelesClassClinVar
rs25406711188:141,542,211C/G—uncertain significance
rs25406711848:141,542,244C/A—likely pathogenic
rs25406720458:141,542,525C/T—uncertain significance
rs25406721678:141,542,573A/G—uncertain significance
rs25406722418:141,542,594A/G—uncertain significance
rs14677550298:141,542,597C/T—likely pathogenic
rs3728837328:141,542,598G/A—likely benign
rs25406723318:141,542,611C/T—uncertain significance
rs21328541588:141,542,621T/G—uncertain significance
rs25406725758:141,542,691A/C—uncertain significance
rs25406725898:141,542,692T/C—uncertain significance
rs14752643798:141,545,578C/T—uncertain significance
rs20726804618:141,545,586C/T—pathogenic
rs25406797448:141,545,609G/A—likely benign
rs25406798008:141,545,626T/A—uncertain significance
rs20726816898:141,545,641C/G—pathogenic
rs29447728:141,548,419C/Gintron variant—
rs737131698:141,549,412A/G—benign
rs8669817538:141,549,448G/A—pathogenic
rs7656481108:141,549,561T/C—likely benign
rs20727909588:141,551,310G/A—uncertain significance
rs7454189168:141,551,326C/T—likely benign
rs1132245098:141,551,368G/A—benign
rs25406910848:141,551,379G/T—conflicting classifications of pathogenicity
rs22939398:141,551,407G/A—benign
rs12053535668:141,551,408C/T—uncertain significance
rs11969705588:141,551,427G/A—uncertain significance
rs7571968228:141,551,440G/C—uncertain significance
rs15640772078:141,554,341C/T—pathogenic
rs1902661668:141,554,342G/A—benign
rs15640772208:141,554,344C/T—uncertain significance
rs20728521478:141,554,346G/C—uncertain significance
rs1429770658:141,554,348G/C—likely benign
rs1511291678:141,554,362C/G—uncertain significance
rs14098857198:141,554,377T/C—uncertain significance
rs2012143988:141,554,406C/T—likely benign
rs25407046058:141,557,573T/C—uncertain significance
rs578105038:141,557,608G/C—benign
rs25407047008:141,557,612T/C—uncertain significance
rs25407047228:141,557,630T/C—uncertain significance
rs21328986268:141,557,652T/G—uncertain significance
rs25407048898:141,557,696A/G—likely pathogenic
rs3776469388:141,557,730A/C—benign
rs29774798:141,558,632G/Cregulatory region variant—
rs7600592718:141,559,224G/A—uncertain significance
rs1503389098:141,559,232G/Asynonymous variant—
rs20729528708:141,559,249C/A—uncertain significance
rs604749488:141,559,268C/T—benign
rs7475877448:141,559,357C/T—uncertain significance
rs22927818:141,559,358G/A—benign
rs25407088048:141,559,402A/C—uncertain significance
rs22927798:141,561,393G/Cintron variantbenign
rs25407134438:141,561,434G/A—likely benign
rs13841490308:141,561,457C/T—uncertain significance
rs25407135938:141,561,475T/C—uncertain significance
rs25407136738:141,561,504A/C—uncertain significance
rs751341718:141,565,991G/A—likely benign
rs13088283078:141,566,084C/T—uncertain significance
rs617581368:141,566,293G/T—likely benign
rs1443818198:141,566,299C/T—likely benign
rs22717388:141,566,311C/T—benign
rs25407266438:141,566,319T/C—likely pathogenic
rs20730922348:141,566,321A/G—pathogenic
rs21329286478:141,566,339T/A—uncertain significance
rs20730923988:141,566,340C/T—uncertain significance
rs20730924968:141,566,342G/A—pathogenic
rs25407296878:141,567,195G/T—likely pathogenic
rs25407296928:141,567,199G/A—likely benign
rs21329315558:141,567,315C/T—uncertain significance
rs25496255778:141,568,623C/T—uncertain significance
rs25496255838:141,568,641T/C—uncertain significance
rs25496261358:141,569,562T/C—uncertain significance
rs20731607458:141,569,599G/C—uncertain significance
rs7619157558:141,569,607T/C—uncertain significance
rs7677825538:141,569,615C/T—likely benign
rs1404234298:141,570,513G/T—likely benign
rs21329411258:141,570,526C/A—pathogenic
rs25496267918:141,570,532C/T—uncertain significance
rs10051127008:141,570,542G/A—uncertain significance
rs21329411618:141,570,548C/T—uncertain significance
rs20731796588:141,570,553A/G—pathogenic
rs14354636508:141,570,568C/G—uncertain significance
rs10487191608:141,570,577G/A—uncertain significance
rs39286728:141,572,167C/Tintron variant—
rs7588978618:141,572,596C/T—likely benign
rs7644263948:141,572,610C/T—uncertain significance
rs7530588768:141,572,646C/T—uncertain significance
rs5308875768:141,572,659G/T—uncertain significance
rs25496280878:141,572,668C/G—uncertain significance
rs10159259548:141,572,717G/A—uncertain significance
rs13458695188:141,572,721C/A—uncertain significance
rs3689452188:141,572,740G/A—uncertain significance
rs29447558:141,574,194A/T——
rs132769588:141,582,896T/C—benign
rs3710720768:141,582,903G/A—likely benign
rs20734030308:141,582,933G/A—uncertain significance
rs25496341148:141,582,970C/T—uncertain significance
rs3714011888:141,582,971G/C—likely benign
rs25496341338:141,582,980A/T—uncertain significance
rs7795234368:141,583,025G/A—likely benign

Showing 100 of 108 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.