PDE10A

phosphodiesterase 10A

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

Known Variants230 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7533030006:165,746,528C/A—uncertain significance
rs7785707876:165,746,542G/A—uncertain significance
rs1498199236:165,746,547G/A—likely benign
rs17814350666:165,746,554G/T—uncertain significance
rs24836120116:165,746,575T/C—uncertain significance
rs1457225156:165,746,584C/T—uncertain significance
rs24836123316:165,746,591C/T—uncertain significance
rs3695578846:165,746,631T/C—likely benign
rs21281728266:165,746,632G/A—likely benign
rs3773556296:165,749,635C/T—uncertain significance
rs7519099826:165,749,636G/A—uncertain significance
rs1437188756:165,749,644G/C—benign
rs1488452276:165,749,665A/G—likely benign
rs12235219096:165,749,666T/G—uncertain significance
rs5405590986:165,749,682C/T—uncertain significance
rs353706076:165,749,683G/A—likely benign
rs1467760516:165,749,695C/T—benign
rs13033207256:165,749,710T/C—likely benign
rs24836443036:165,749,719C/G—likely benign
rs7809040086:165,752,755A/G—likely benign
rs1886539886:165,752,757T/C—benign
rs24836700806:165,752,788C/T—likely benign
rs1481383806:165,752,812A/C—uncertain significance
rs21281778536:165,752,827C/T—likely benign
rs7669022136:165,752,854T/C—uncertain significance
rs7543876756:165,752,855G/T—conflicting classifications of pathogenicity
rs15542402016:165,756,886C/T—uncertain significance
rs1178262556:165,756,927C/T—uncertain significance
rs1451108396:165,756,928G/A—likely benign
rs24837004846:165,756,980A/C—likely pathogenic
rs13061067536:165,792,700A/G—likely benign
rs1422621846:165,792,709T/C—likely benign
rs7803511136:165,792,715G/A—likely benign
rs7691653536:165,792,724C/T—uncertain significance
rs21282069016:165,792,737T/C—uncertain significance
rs25336053876:165,792,789G/C—uncertain significance
rs7608707346:165,792,796C/G—uncertain significance
rs17847978836:165,792,817A/C—uncertain significance
rs25336060306:165,792,857T/C—uncertain significance
rs5293834016:165,792,870C/A—benign
rs7806271716:165,792,872A/T—benign
rs3736278216:165,801,769C/T—likely benign
rs5776007156:165,801,770G/A—likely benign
rs1893444926:165,801,772C/T—likely benign
rs1154819506:165,801,773G/A—benign
rs10334179716:165,801,787C/T—uncertain significance
rs15117466:165,801,790G/A—benign
rs25336589056:165,801,796G/A—likely benign
rs17854450556:165,801,802A/G—likely benign
rs17854459776:165,801,822G/A—pathogenic
rs25336590866:165,801,827A/G—uncertain significance
rs7588382836:165,801,853C/T—likely benign
rs1392677256:165,801,865G/A—likely benign
rs21282129066:165,801,878T/C—uncertain significance
rs1400981476:165,801,922C/T—likely benign
rs7534825086:165,801,957A/G—likely benign
rs3761923326:165,801,958T/C—likely benign
rs3713938956:165,801,962G/A—likely benign
rs1822102306:165,806,122A/G—benign
rs3741520836:165,806,151A/T—uncertain significance
rs1484537846:165,806,153C/T—likely benign
rs7701623426:165,806,154G/T—uncertain significance
rs7578461386:165,806,162G/T—uncertain significance
rs21282158656:165,806,183G/T—uncertain significance
rs1476172496:165,806,198G/A—likely benign
rs7495819706:165,806,202G/T—uncertain significance
rs25336894946:165,806,228C/A—likely benign
rs7693471056:165,806,257T/C—uncertain significance
rs25336899516:165,806,260A/C—uncertain significance
rs617333916:165,808,684G/T—benign
rs799373396:165,808,688C/T—likely benign
rs1401356286:165,808,695C/T—conflicting classifications of pathogenicity
rs7745401366:165,808,708A/C—uncertain significance
rs617333926:165,808,716G/C—likely benign
rs7551121106:165,808,762T/G—likely benign
rs7596348826:165,809,831C/T—uncertain significance
rs17861600816:165,809,841G/A—likely benign
rs7502416656:165,809,879T/C—uncertain significance
rs7545053616:165,809,889G/A—likely benign
rs7785703476:165,809,904C/T—likely benign
rs5488530446:165,809,922C/T—benign
rs1117373946:165,809,940A/T—uncertain significance
rs7600318616:165,809,957C/T—likely benign
rs7698497036:165,809,962C/G—likely benign
rs122108326:165,814,736A/G——
rs1450916756:165,827,021C/T—uncertain significance
rs14385250876:165,827,075T/C—uncertain significance
rs12651361546:165,827,106G/C—uncertain significance
rs11929048986:165,827,114G/A—uncertain significance
rs12077654196:165,827,125G/T—uncertain significance
rs7652313916:165,827,145C/G—likely benign
rs3690627966:165,827,179T/C—likely benign
rs2207496:165,827,194G/A—benign
rs14477440126:165,829,657C/T—likely benign
rs17882989976:165,829,668A/G—likely benign
rs15542586816:165,829,670T/C—uncertain significance
rs25338701836:165,829,671T/A—uncertain significance
rs17883011856:165,829,700G/A—likely benign
rs7510577296:165,829,708G/T—uncertain significance
rs7568978326:165,829,712G/A—likely benign

Showing 100 of 230 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.