rs2412971
This is a intron variant variant in the HORMAD2 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
lymphocyte percentage of leukocytes
Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.03
p 5.0e-35
N 408,112
Large GWAS
European
hypothyroidism
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.05
p 1.0e-14
N 626,411
Major Consortium StudyLarge GWAS
multi-ancestry
IGA glomerulonephritis
Li M et al. “Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy.” Journal of the American Society of Nephrology : Jasn 31(12):2949-2963 (2020)
Allele G
OR 1.31
p 6.0e-13
N 14,191
Meta-analysisLarge GWAS
multi-ancestry
Kiryluk K et al. “Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.” Nature Genetics 46(11):1187-96 (2014)
Allele G
OR 1.20
p 5.0e-12
N 6,699
Large GWAS
multi-ancestry
tonsillectomy risk measurement
Feenstra B et al. “Genome-wide association study identifies variants in HORMAD2 associated with tonsillectomy.” Journal of Medical Genetics 54(5):358-364 (2017)
Allele G
OR 1.22
p 1.0e-9
N 13,483
Large GWAS
European
About HORMAD2
Predicted to be involved in meiotic cell cycle and meiotic sister chromatid cohesion. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all HORMAD2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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