rs4409785

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (18)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Thyroid preparation use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.15
p 2.0e-35
N 484,308
Large GWAS
multi-ancestry
Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele C
OR 0.14
p 2.0e-32
N 305,582
Major Consortium StudyLarge GWAS
European

autoimmune thyroid disease

Saevarsdottir S et al. “FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.” Nature 584(7822):619-623 (2020)
Allele C
OR 1.15
p 2.0e-31
N 754,406
Large GWAS
European
Zeng Y et al. “Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.” The American Journal of Psychiatry 180(4):294-304 (2023)
Allele C
OR 1.14
p 1.0e-24
N 376,871
Large GWAS
European

Graves disease

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele C
OR 0.16
p 1.0e-26
N 2,460,657
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.20
p 7.0e-9
N 634,085
Large GWAS
multi-ancestry

basal cell carcinoma

Seviiri M et al. “A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma.” Nature Communications 13(1):7650 (2022)
Allele C
OR —
p 7.0e-23
N 307,684
Large GWAS
European

sex hormone-binding globulin measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele C
OR 0.03
p 3.0e-15
N 322,484
Major Consortium StudyLarge GWAS
multi-ancestry
Harrison S et al. “Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank.” Science Advances 7(31) (2021)
Allele C
OR 1.02
p 3.0e-8
N 158,000
Major Consortium StudyLarge GWAS
European

tyrosine measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele C
OR 0.02
p 6.0e-15
N 450,015
Large GWAS
multi-ancestry

Vitiligo

Jin Y et al. “Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.” Nature Genetics 44(6):676-80 (2012)
Allele C
OR 1.34
p 2.0e-13
N 3,228
Large GWAS
European

multiple sclerosis

“Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.” Science (new York, N.y.) 365(6460) (2019)
Allele C
OR 1.09
p 7.0e-12
N 41,505
Large GWAS
multi-ancestry

Myasthenia gravis

Braun A et al. “Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.” Nature Communications 15(1):9839 (2024)
Allele C
OR 1.14
p 1.0e-11
N 437,736
Meta-analysisLarge GWAS
European

skin neoplasm

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 2.0e-11
N 429,041
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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