Trait
SNPs associated with Multiple Sclerosis
375 genetic variants across 113 genes have been associated with Multiple Sclerosis in published research. Key genes include AGAP2, AHI1, AHI1-DT.
Associated variants375 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs3135388 | HLA-DRA | GWAS association (p=9.0e-81) | Meta-analysis |
| rs1800693 | TNFRSF1A | GWAS association (p=4.0e-14) | Meta-analysis |
| rs2523393 | HLA-F | GWAS association (p=1.0e-17) | Meta-analysis |
| rs2104286 | IL2RA | Higher multiple sclerosis risk | Meta-analysis |
| rs2300747 | CD58 | GWAS association (p=3.0e-10) | Meta-analysis |
| rs17445836 | LOC124903741 | GWAS association (p=4.0e-09) | Meta-analysis |
| rs17824933 | CD6 | GWAS association (p=4.0e-09) | Meta-analysis |
| rs12722489 | IL2RA | Higher multiple sclerosis risk | Meta-analysis |
| rs2004640 | IRF5 | Increased risk of multiple sclerosis | Meta-analysis |
| rs9268925 | — | GWAS association (p=1.0e-95) | Major Consortium Study |
| rs4640926 | — | GWAS association (p=7.0e-62) | Major Consortium Study |
| rs534042811 | — | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs190973077 | MIDEAS | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs141495019 | RAD17 | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs184104263 | — | GWAS association (p=7.0e-12) | Major Consortium Study |
| rs138222859 | — | GWAS association (p=9.0e-12) | Major Consortium Study |
| rs559664213 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs367798757 | MACROD2 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs150626530 | SLIT3 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs368479978 | EPS8L3 | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs570181105 | LINC01100 | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs3104373 | — | GWAS association (p=1.0e-234) | Large GWAS |
| rs3129889 | — | GWAS association (p=1.0e-206) | Large GWAS |
| rs9271366 | — | GWAS association (p=7.0e-184) | Large GWAS |
| rs10801908 | — | GWAS association (p=5.0e-70) | Large GWAS |
| rs11256593 | — | GWAS association (p=3.0e-65) | Large GWAS |
| rs438613 | LINC01967 | GWAS association (p=2.0e-49) | Large GWAS |
| rs12927355 | — | GWAS association (p=6.0e-46) | Large GWAS |
| rs6677309 | — | GWAS association (p=5.0e-42) | Large GWAS |
| rs6670198 | PRXL2B | GWAS association (p=2.0e-36) | Large GWAS |
| rs62420820 | — | GWAS association (p=9.0e-36) | Large GWAS |
| rs1738074 | TAGAP | GWAS association (p=7.0e-15) | Large GWAS |
| rs35540610 | — | GWAS association (p=3.0e-33) | Large GWAS |
| rs1323292 | LOC105371664 | GWAS association (p=2.0e-08) | Large GWAS |
| rs1077667 | TNFSF14 | GWAS association (p=9.0e-14) | Large GWAS |
| rs1813375 | — | GWAS association (p=2.0e-32) | Large GWAS |
| rs35486093 | — | GWAS association (p=2.0e-31) | Large GWAS |
| rs2150879 | — | GWAS association (p=4.0e-31) | Large GWAS |
| rs701006 | — | GWAS association (p=1.0e-30) | Large GWAS |
| rs11809700 | EVI5 | GWAS association (p=3.0e-30) | Large GWAS |
| rs9843355 | — | GWAS association (p=4.0e-30) | Large GWAS |
| rs4939490 | — | GWAS association (p=2.0e-29) | Large GWAS |
| rs4896153 | AHI1-DT | GWAS association (p=3.0e-29) | Large GWAS |
| rs72928038 | — | GWAS association (p=8.0e-29) | Large GWAS |
| rs1026916 | STAT3 | GWAS association (p=2.0e-28) | Large GWAS |
| rs10063294 | IL7R | GWAS association (p=2.0e-28) | Large GWAS |
| rs1014486 | — | GWAS association (p=3.0e-28) | Large GWAS |
| rs11079784 | — | GWAS association (p=2.0e-27) | Large GWAS |
| rs41286801 | — | GWAS association (p=1.0e-26) | Large GWAS |
| rs3748817 | MMEL1 | GWAS association (p=1.0e-26) | Large GWAS |
| rs6589706 | — | GWAS association (p=5.0e-26) | Large GWAS |
| rs631204 | — | GWAS association (p=5.0e-25) | Large GWAS |
| rs11749040 | — | GWAS association (p=5.0e-25) | Large GWAS |
| rs4808760 | — | GWAS association (p=6.0e-25) | Large GWAS |
| rs2255214 | — | GWAS association (p=1.0e-24) | Large GWAS |
| rs11554159 | IFI30 | GWAS association (p=2.0e-24) | Large GWAS |
| rs12478539 | — | GWAS association (p=2.0e-24) | Large GWAS |
| rs58166386 | EPS15L1 | GWAS association (p=4.0e-24) | Large GWAS |
| rs7977720 | — | GWAS association (p=5.0e-24) | Large GWAS |
| rs1131265 | TIMMDC1 | GWAS association (p=1.0e-23) | Large GWAS |
| rs34947566 | LOC105371082 | GWAS association (p=1.0e-23) | Large GWAS |
| rs17066096 | — | GWAS association (p=6.0e-13) | Large GWAS |
| rs8070345 | — | GWAS association (p=2.0e-23) | Large GWAS |
| rs1250551 | — | GWAS association (p=2.0e-23) | Large GWAS |
| rs9989735 | SP140 | GWAS association (p=4.0e-23) | Large GWAS |
| rs34383631 | — | GWAS association (p=4.0e-23) | Large GWAS |
| rs7200786 | CLEC16A | GWAS association (p=9.0e-17) | Large GWAS |
| rs34723276 | — | GWAS association (p=1.0e-22) | Large GWAS |
| rs7078535 | — | GWAS association (p=2.0e-22) | Large GWAS |
| rs28703878 | — | GWAS association (p=5.0e-22) | Large GWAS |
| rs1920296 | — | GWAS association (p=7.0e-22) | Large GWAS |
| rs201202118 | TSFM | GWAS association (p=9.0e-22) | Large GWAS |
| rs140522 | ODF3B | GWAS association (p=2.0e-08) | Large GWAS |
| rs3809627 | TBX6 | GWAS association (p=1.0e-21) | Large GWAS |
| rs67111717 | RGS14 | GWAS association (p=3.0e-21) | Large GWAS |
| rs59655222 | INAVA | GWAS association (p=6.0e-21) | Large GWAS |
| rs212405 | TAGAP-AS1 | GWAS association (p=8.0e-21) | Large GWAS |
| rs12087340 | — | GWAS association (p=1.0e-20) | Large GWAS |
| rs2040406 | LOC124901301 | GWAS association (p=1.0e-20) | Large GWAS |
| rs74796499 | — | GWAS association (p=2.0e-20) | Large GWAS |
| rs11154801 | AHI1 | GWAS association (p=1.0e-13) | Large GWAS |
| rs2364485 | — | GWAS association (p=2.0e-20) | Large GWAS |
| rs4796791 | — | GWAS association (p=4.0e-20) | Large GWAS |
| rs7090512 | — | GWAS association (p=5.0e-20) | Large GWAS |
| rs1359062 | LOC105371664 | GWAS association (p=5.0e-20) | Large GWAS |
| rs2331964 | — | GWAS association (p=5.0e-20) | Large GWAS |
| rs6990534 | — | GWAS association (p=6.0e-20) | Large GWAS |
| rs6880778 | — | GWAS association (p=8.0e-20) | Large GWAS |
| rs2327586 | — | GWAS association (p=9.0e-20) | Large GWAS |
| rs9610458 | — | GWAS association (p=1.0e-19) | Large GWAS |
| rs12925972 | — | GWAS association (p=1.0e-19) | Large GWAS |
| rs9591325 | — | GWAS association (p=1.0e-19) | Large GWAS |
| rs1177228 | — | GWAS association (p=2.0e-19) | Large GWAS |
| rs12365699 | — | GWAS association (p=2.0e-19) | Large GWAS |
| rs2248137 | CYP24A1 | GWAS association (p=2.0e-19) | Large GWAS |
| rs1076928 | — | GWAS association (p=3.0e-19) | Large GWAS |
| rs1087056 | LOC105376481 | GWAS association (p=3.0e-19) | Large GWAS |
| rs55838263 | INAVA | GWAS association (p=4.0e-19) | Large GWAS |
| rs28834106 | — | GWAS association (p=4.0e-19) | Large GWAS |
| rs2546890 | LOC285626 | GWAS association (p=1.0e-11) | Large GWAS |
Showing the top 100 of 375 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.