rs58166386

This is a intron variant variant in the EPS15L1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

multiple sclerosis

“Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.” Science (new York, N.y.) 365(6460) (2019)

Allele G

OR 1.11

p 4.0e-24

N 41,505

Large GWAS

multi-ancestry

About EPS15L1

Enables cadherin binding activity. Predicted to be involved in endosomal transport and synaptic vesicle endocytosis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

View all EPS15L1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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