TNFSF14
TNF superfamily member 14
Summary
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs344562 | 19:6,661,549 | T/A | — | — |
| rs79452416 | 19:6,664,955 | G/A | — | benign |
| rs150171386 | 19:6,665,007 | C/T | — | uncertain significance |
| rs344560 | 19:6,665,020 | T/C | missense variant | — |
| rs145049392 | 19:6,665,057 | G/A | — | benign |
| rs140486559 | 19:6,665,095 | G/A | — | uncertain significance |
| rs781390768 | 19:6,665,310 | T/C | — | uncertain significance |
| rs553799062 | 19:6,665,341 | C/T | — | uncertain significance |
| rs757864251 | 19:6,665,343 | G/A | — | uncertain significance |
| rs755412166 | 19:6,665,361 | C/T | — | uncertain significance |
| rs780161535 | 19:6,667,451 | C/T | — | uncertain significance |
| rs1077667 | 19:6,668,972 | C/T | regulatory region variant | — |
| rs757186501 | 19:6,669,947 | A/G | — | uncertain significance |
| rs2291667 | 19:6,669,986 | G/A | missense variant | — |
| rs375195247 | 19:6,669,989 | T/C | — | likely benign |
| rs138116115 | 19:6,670,024 | G/A | — | benign |
| rs1403193430 | 19:6,670,037 | C/A | — | uncertain significance |
| rs143389888 | 19:6,670,070 | C/A | — | likely benign |
| rs182667414 | 19:6,670,628 | C/T | regulatory region variant | — |
| rs542250234 | 19:6,671,235 | G/T | — | — |
| rs12461821 | 19:6,671,369 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.