TAGAP
T cell activation RhoGTPase activating protein
Summary
This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4709267 | 6:159,456,375 | A/G | 3 prime UTR variant | — |
| rs1425584735 | 6:159,456,999 | G/A | — | uncertain significance |
| rs1309844912 | 6:159,457,056 | A/T | — | uncertain significance |
| rs193056043 | 6:159,457,149 | G/C | — | uncertain significance |
| rs145572935 | 6:159,457,395 | C/T | — | uncertain significance |
| rs999647038 | 6:159,457,421 | T/C | — | uncertain significance |
| rs2484988644 | 6:159,457,507 | G/C | — | uncertain significance |
| rs2484989014 | 6:159,457,592 | T/C | — | uncertain significance |
| rs1159612053 | 6:159,457,655 | G/T | — | uncertain significance |
| rs1463621498 | 6:159,457,677 | A/G | — | uncertain significance |
| rs2484990364 | 6:159,457,872 | G/C | — | uncertain significance |
| rs1424366220 | 6:159,457,883 | C/T | — | uncertain significance |
| rs112777023 | 6:159,458,016 | G/T | — | benign |
| rs35263580 | 6:159,458,018 | C/T | — | benign |
| rs61753626 | 6:159,458,024 | C/T | — | benign |
| rs112913154 | 6:159,459,194 | G/A | — | benign |
| rs2484995217 | 6:159,459,245 | C/T | — | uncertain significance |
| rs758549217 | 6:159,459,251 | G/C | — | uncertain significance |
| rs2484999541 | 6:159,460,185 | C/G | — | uncertain significance |
| rs751800889 | 6:159,460,322 | G/A | — | uncertain significance |
| rs1345861383 | 6:159,460,340 | C/T | — | uncertain significance |
| rs774261461 | 6:159,461,786 | C/A | — | uncertain significance |
| rs925042321 | 6:159,462,533 | A/C | — | uncertain significance |
| rs752195559 | 6:159,462,535 | T/C | — | uncertain significance |
| rs16889420 | 6:159,462,896 | C/G | coding sequence variant | — |
| rs75290071 | 6:159,463,605 | C/G | coding sequence variant | — |
| rs2485015141 | 6:159,464,683 | T/C | — | uncertain significance |
| rs1738074 | 6:159,465,977 | T/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.