rs4709267
This is a 3 prime utr variant variant in the TAGAP gene.
▶Research that mentions this SNP (1)
▶Association of single‐nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African AmericansAssociationN=1,179Perkins EA et al.(2012)· Arthritis & Rheumatism
This case-control study of 446 African-American RA patients and 733 controls identified three SNPs significantly associated with rheumatoid arthritis: TNFAIP3 rs719149 (A allele OR 1.22, p=0.02), TAGAP rs1738074 (G allele OR 0.75, p=0.0012), and TAGAP rs4709267 (G allele OR 0.74, p=0.004). Conditional analyses suggest the two TAGAP SNPs have independent effects despite weak linkage disequilibrium (R²=0.034).
About TAGAP
This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
View all TAGAP variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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