rs7847663

This variant is located in the PTCSC2 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hypothyroidism

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.28

p 9.9e-324

N 626,411

Major Consortium StudyLarge GWAS

multi-ancestry

Hashimoto's thyroiditis

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele T

OR 0.20

p 1.0e-50

N 1,815,514

Large GWAS

multi-ancestry

Thyroid stimulating hormone level

Nielsen TR et al. “A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents.” Plos One 12(3):e0174204 (2017)

Allele T

OR 0.22

p 2.0e-20

N 1,680

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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