LPP
LIM domain containing preferred translocation partner in lipoma
Summary
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Known Variants142 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1975991 | 3:187,944,924 | A/C | — | — |
| rs66702144 | 3:188,028,097 | G/A | intron variant | — |
| rs4420855 | 3:188,057,207 | A/G | intron variant | — |
| rs9877579 | 3:188,058,716 | T/G | — | — |
| rs9865818 | 3:188,072,513 | A/C | — | — |
| rs182054151 | 3:188,079,499 | C/T | intron variant | — |
| rs4686953 | 3:188,082,919 | T/C | intron variant | — |
| rs9878655 | 3:188,083,490 | T/C | intron variant | — |
| rs9864554 | 3:188,084,682 | G/T | intron variant | — |
| rs9851967 | 3:188,087,628 | C/T | intron variant | — |
| rs11719821 | 3:188,088,318 | T/C | intron variant | — |
| rs13076312 | 3:188,089,254 | C/A | — | — |
| rs62291440 | 3:188,092,546 | G/C | — | — |
| rs139785987 | 3:188,093,707 | G/T | — | — |
| rs115288350 | 3:188,100,043 | G/A | intron variant | — |
| rs2030517 | 3:188,101,703 | A/T | — | — |
| rs13080163 | 3:188,102,104 | G/T | intron variant | — |
| rs2889896 | 3:188,102,716 | C/T | intron variant | — |
| rs4686955 | 3:188,106,379 | A/G | intron variant | — |
| rs1464510 | 3:188,112,554 | C/G | — | — |
| rs111983924 | 3:188,112,641 | C/A | — | — |
| rs9834159 | 3:188,115,232 | T/C | — | — |
| rs9815073 | 3:188,115,682 | C/G | — | — |
| rs6790260 | 3:188,117,079 | C/T | — | — |
| rs6444285 | 3:188,117,786 | C/T | intron variant | — |
| rs4686484 | 3:188,118,572 | G/A | regulatory region variant | — |
| rs7640006 | 3:188,123,698 | T/C | — | benign |
| rs3732911 | 3:188,123,819 | G/T | — | benign |
| rs147232499 | 3:188,123,940 | G/A | — | uncertain significance |
| rs183529256 | 3:188,123,972 | C/T | — | likely benign |
| rs145658316 | 3:188,124,077 | C/G | — | uncertain significance |
| rs2482321982 | 3:188,124,096 | G/T | — | uncertain significance |
| rs1559810 | 3:188,124,354 | A/C | — | benign |
| rs13093110 | 3:188,125,120 | C/T | intron variant | — |
| rs73192661 | 3:188,128,794 | C/T | intron variant | — |
| rs9860547 | 3:188,128,979 | G/A | intron variant | — |
| rs138727849 | 3:188,133,145 | C/T | intron variant | — |
| rs113535261 | 3:188,142,092 | A/G | intron variant | — |
| rs115233654 | 3:188,155,723 | C/G | — | — |
| rs34057316 | 3:188,194,907 | G/A | — | — |
| rs768685184 | 3:188,202,485 | A/C | — | uncertain significance |
| rs2067078 | 3:188,202,550 | T/A | — | benign |
| rs1559814 | 3:188,202,582 | G/T | — | benign |
| rs573587958 | 3:188,203,412 | C/T | — | — |
| rs775318089 | 3:188,242,486 | C/T | — | uncertain significance |
| rs201958080 | 3:188,242,564 | C/T | — | uncertain significance |
| rs56275744 | 3:188,242,681 | G/T | — | benign |
| rs373734498 | 3:188,242,693 | T/G | — | benign |
| rs369579197 | 3:188,242,697 | T/G | — | benign |
| rs138209867 | 3:188,242,701 | T/G | — | benign |
| rs144299808 | 3:188,242,705 | T/G | — | benign |
| rs1025190 | 3:188,265,404 | T/A | intron variant | — |
| rs10937355 | 3:188,289,697 | C/T | upstream gene variant | — |
| rs1849913 | 3:188,298,989 | G/A | intron variant | — |
| rs6444305 | 3:188,299,902 | G/C | — | — |
| rs747952496 | 3:188,311,659 | G/A | — | — |
| rs35417432 | 3:188,326,955 | A/G | — | benign |
| rs35746269 | 3:188,326,970 | T/C | — | uncertain significance |
| rs755340785 | 3:188,326,974 | C/T | — | uncertain significance |
| rs780877086 | 3:188,326,976 | C/A | — | uncertain significance |
| rs150267429 | 3:188,326,983 | C/T | — | uncertain significance |
| rs138963849 | 3:188,326,984 | G/A | — | likely benign |
| rs1472314713 | 3:188,326,986 | C/T | — | uncertain significance |
| rs149437411 | 3:188,327,019 | C/T | — | likely benign |
| rs1236336023 | 3:188,327,052 | C/G | — | uncertain significance |
| rs1207638500 | 3:188,327,072 | G/T | — | uncertain significance |
| rs763711423 | 3:188,327,096 | G/C | — | uncertain significance |
| rs55674610 | 3:188,327,107 | C/T | — | benign |
| rs761464722 | 3:188,327,150 | A/G | — | uncertain significance |
| rs150830431 | 3:188,327,154 | C/T | — | likely benign |
| rs750601343 | 3:188,327,171 | A/T | — | uncertain significance |
| rs749464346 | 3:188,327,175 | C/T | — | uncertain significance |
| rs777556416 | 3:188,327,190 | A/T | — | uncertain significance |
| rs775933619 | 3:188,327,199 | C/T | — | uncertain significance |
| rs146472491 | 3:188,327,256 | C/T | — | likely benign |
| rs2479091401 | 3:188,327,264 | C/A | — | uncertain significance |
| rs35940579 | 3:188,327,294 | T/C | — | benign |
| rs145531948 | 3:188,327,303 | T/C | — | uncertain significance |
| rs1275870991 | 3:188,327,327 | G/A | — | uncertain significance |
| rs201035440 | 3:188,327,367 | C/T | — | uncertain significance |
| rs2479101529 | 3:188,327,376 | G/A | — | uncertain significance |
| rs75280063 | 3:188,327,388 | C/T | — | uncertain significance |
| rs146504550 | 3:188,327,412 | A/G | — | uncertain significance |
| rs760166726 | 3:188,327,425 | A/G | — | likely benign |
| rs2479107339 | 3:188,327,441 | G/A | — | uncertain significance |
| rs1059380 | 3:188,327,461 | C/T | — | benign |
| rs912177495 | 3:188,327,463 | C/A | — | uncertain significance |
| rs769719964 | 3:188,327,552 | A/T | — | uncertain significance |
| rs7645635 | 3:188,327,555 | T/C | — | benign |
| rs570145252 | 3:188,327,562 | T/A | — | uncertain significance |
| rs142661833 | 3:188,327,585 | A/G | — | uncertain significance |
| rs777646093 | 3:188,327,593 | T/A | — | uncertain significance |
| rs146042962 | 3:188,327,606 | C/T | — | benign |
| rs139912286 | 3:188,327,614 | G/A | — | likely benign |
| rs2479123251 | 3:188,327,628 | C/T | — | uncertain significance |
| rs3732909 | 3:188,327,683 | T/C | — | benign |
| rs17670280 | 3:188,400,239 | G/C | intron variant | — |
| rs55661102 | 3:188,401,138 | A/G | regulatory region variant | — |
| rs17607589 | 3:188,402,586 | C/T | upstream gene variant | — |
| rs9846404 | 3:188,412,997 | T/A | regulatory region variant | — |
Showing 100 of 142 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.