rs1975991

This variant is located in the LPP gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

trait in response to atorvastatin

Mykkänen AJH et al. “Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP.” Clinical Pharmacology and Therapeutics 115(6):1428-1440 (2024)
Allele A
OR —
β 0.280
p 4.0e-8
N 158
Small GWAS
European

About LPP

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

View all LPP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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