THAP4
THAP domain containing 4
Summary
Enables several functions, including heme binding activity; nitric oxide binding activity; and peroxynitrite isomerase activity. Involved in nitrate metabolic process and tyrosine metabolic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants44 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs776901781 | 2:242,524,025 | G/A | — | uncertain significance |
| rs757030411 | 2:242,524,058 | T/C | — | uncertain significance |
| rs755678319 | 2:242,524,076 | G/A | — | uncertain significance |
| rs772714347 | 2:242,524,094 | G/A | — | uncertain significance |
| rs62193000 | 2:242,534,709 | C/T | intron variant | — |
| rs146928309 | 2:242,541,412 | C/T | — | uncertain significance |
| rs756590530 | 2:242,542,397 | C/A | — | uncertain significance |
| rs770996870 | 2:242,542,465 | T/G | — | uncertain significance |
| rs6414219 | 2:242,544,962 | A/T | intron variant | — |
| rs751800435 | 2:242,545,810 | C/G | — | uncertain significance |
| rs757514473 | 2:242,545,811 | C/T | — | uncertain significance |
| rs947659138 | 2:242,545,871 | G/A | — | uncertain significance |
| rs199972436 | 2:242,545,886 | G/A | — | uncertain significance |
| rs7566688 | 2:242,570,441 | C/T | intron variant | — |
| rs762065419 | 2:242,572,422 | C/T | — | uncertain significance |
| rs1280828791 | 2:242,572,458 | C/T | — | uncertain significance |
| rs765880797 | 2:242,572,511 | T/G | — | uncertain significance |
| rs2067588912 | 2:242,572,610 | C/T | — | uncertain significance |
| rs773148152 | 2:242,572,701 | C/T | — | uncertain significance |
| rs769419458 | 2:242,572,850 | G/A | — | uncertain significance |
| rs770943923 | 2:242,572,920 | T/C | — | uncertain significance |
| rs1308950384 | 2:242,572,940 | G/A | — | uncertain significance |
| rs199732559 | 2:242,572,946 | C/T | — | uncertain significance |
| rs142582018 | 2:242,572,953 | C/T | — | uncertain significance |
| rs758509664 | 2:242,572,968 | C/T | — | likely benign |
| rs778022736 | 2:242,572,977 | C/T | — | uncertain significance |
| rs202065824 | 2:242,572,986 | C/T | — | uncertain significance |
| rs2549666268 | 2:242,572,989 | T/C | — | uncertain significance |
| rs147957437 | 2:242,572,997 | G/T | — | uncertain significance |
| rs768237010 | 2:242,572,998 | C/T | — | uncertain significance |
| rs765664782 | 2:242,573,043 | C/T | — | uncertain significance |
| rs1401683644 | 2:242,573,081 | T/C | — | uncertain significance |
| rs757389718 | 2:242,573,088 | C/T | — | uncertain significance |
| rs1057108798 | 2:242,573,162 | G/A | — | uncertain significance |
| rs774683488 | 2:242,573,168 | G/A | — | likely benign |
| rs377643671 | 2:242,573,199 | C/T | — | likely benign |
| rs2549666481 | 2:242,573,202 | C/T | — | uncertain significance |
| rs758331582 | 2:242,573,219 | G/A | — | uncertain significance |
| rs140227993 | 2:242,573,222 | C/T | — | uncertain significance |
| rs780806360 | 2:242,573,271 | G/A | — | uncertain significance |
| rs779423822 | 2:242,573,276 | C/T | — | uncertain significance |
| rs759486716 | 2:242,573,296 | C/G | — | uncertain significance |
| rs762904738 | 2:242,573,475 | T/C | — | uncertain significance |
| rs545235732 | 2:242,576,401 | G/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.