SMC6
structural maintenance of chromosomes 6
Summary
Enables DNA secondary structure binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular senescence; negative regulation by host of viral genome replication; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants35 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs373222214 | 2:17,846,779 | T/C | — | uncertain significance |
| rs759752308 | 2:17,846,854 | C/T | — | uncertain significance |
| rs756423587 | 2:17,846,866 | C/G | — | uncertain significance |
| rs2545101387 | 2:17,860,160 | T/C | — | uncertain significance |
| rs138881226 | 2:17,860,200 | C/G | — | uncertain significance |
| rs527832932 | 2:17,868,234 | T/C | — | — |
| rs780388886 | 2:17,876,527 | C/T | — | uncertain significance |
| rs755452714 | 2:17,876,528 | G/A | — | uncertain significance |
| rs2545190210 | 2:17,876,534 | G/A | — | uncertain significance |
| rs778578417 | 2:17,877,653 | T/C | — | uncertain significance |
| rs1317973083 | 2:17,883,157 | A/T | — | likely benign |
| rs371569631 | 2:17,884,506 | T/C | — | uncertain significance |
| rs374943544 | 2:17,884,530 | G/A | — | likely benign |
| rs1198661754 | 2:17,888,585 | G/A | — | uncertain significance |
| rs6711251 | 2:17,889,918 | C/T | — | benign |
| rs1487167440 | 2:17,896,155 | C/T | — | uncertain significance |
| rs746103024 | 2:17,897,404 | C/T | — | uncertain significance |
| rs772226192 | 2:17,897,407 | T/G | — | uncertain significance |
| rs747335279 | 2:17,897,413 | C/T | — | uncertain significance |
| rs1303046068 | 2:17,897,496 | T/G | — | uncertain significance |
| rs534834201 | 2:17,898,042 | T/C | — | uncertain significance |
| rs1412161363 | 2:17,898,044 | G/T | — | uncertain significance |
| rs771763705 | 2:17,898,071 | T/C | — | uncertain significance |
| rs1320524744 | 2:17,898,089 | T/C | — | uncertain significance |
| rs780624966 | 2:17,899,443 | T/G | — | uncertain significance |
| rs778847739 | 2:17,899,484 | G/C | — | uncertain significance |
| rs139308239 | 2:17,902,288 | T/G | — | uncertain significance |
| rs1331975747 | 2:17,902,428 | T/C | — | uncertain significance |
| rs2545365435 | 2:17,902,477 | T/G | — | uncertain significance |
| rs2545365452 | 2:17,902,482 | A/C | — | uncertain significance |
| rs373857118 | 2:17,902,510 | G/T | — | uncertain significance |
| rs1669894673 | 2:17,912,391 | G/A | — | uncertain significance |
| rs527767731 | 2:17,912,999 | A/T | intron variant | — |
| rs1485213664 | 2:17,927,116 | T/A | — | uncertain significance |
| rs11900031 | 2:17,930,874 | A/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.