TBC1D21
TBC1 domain family member 21
Summary
Enables GTPase activator activity and small GTPase binding activity. Predicted to be involved in plasma membrane to endosome transport; sperm axoneme assembly; and sperm mitochondrial sheath assembly. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants20 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs773715654 | 15:74,173,771 | A/G | — | uncertain significance |
| rs750336017 | 15:74,173,815 | C/T | — | uncertain significance |
| rs778315942 | 15:74,174,000 | G/A | — | uncertain significance |
| rs994719705 | 15:74,174,004 | G/C | — | uncertain significance |
| rs764368204 | 15:74,174,070 | C/T | — | uncertain significance |
| rs558121058 | 15:74,176,521 | A/G | — | uncertain significance |
| rs745668732 | 15:74,176,556 | C/T | — | uncertain significance |
| rs16958445 | 15:74,176,557 | G/A | missense variant | — |
| rs773244982 | 15:74,177,125 | G/A | — | likely benign |
| rs753261741 | 15:74,177,166 | G/A | — | uncertain significance |
| rs771245536 | 15:74,177,214 | G/A | — | uncertain significance |
| rs763203157 | 15:74,178,912 | C/T | — | uncertain significance |
| rs757779784 | 15:74,178,916 | C/G | — | uncertain significance |
| rs761051787 | 15:74,180,048 | G/A | — | uncertain significance |
| rs1365722834 | 15:74,180,060 | G/A | — | uncertain significance |
| rs1332394395 | 15:74,180,775 | G/A | — | uncertain significance |
| rs183579451 | 15:74,180,789 | G/A | — | uncertain significance |
| rs767678357 | 15:74,180,819 | G/A | — | uncertain significance |
| rs557787710 | 15:74,181,624 | G/A | — | — |
| rs12914489 | 15:74,187,937 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.