TBK1

TANK binding kinase 1

Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]

Known Variants372 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7953177812:64,849,517A/T—likely benign
rs253947657212:64,849,652T/C—uncertain significance
rs155520191912:64,849,654C/T—pathogenic
rs253947658012:64,849,655A/G—uncertain significance
rs11569298312:64,849,659C/T—likely benign
rs76440042912:64,849,664C/A—uncertain significance
rs78132578012:64,849,690A/G—uncertain significance
rs213605273812:64,849,691T/C—uncertain significance
rs76958480312:64,849,701A/G—uncertain significance
rs57672608412:64,849,714A/G—uncertain significance
rs4129201912:64,849,716T/C—benign
rs115708528712:64,849,717G/A—uncertain significance
rs74946112512:64,849,723C/T—uncertain significance
rs253947674112:64,849,729A/G—uncertain significance
rs159235088712:64,849,737G/A—pathogenic
rs14898241612:64,849,745C/T—likely benign
rs37628183312:64,849,754C/T—likely benign
rs14374344212:64,849,786G/C—likely benign
rs729822612:64,849,868C/T—benign
rs7597725912:64,851,568A/G—benign
rs75806174412:64,853,960T/C—likely benign
rs76619103112:64,853,965A/G—likely benign
rs194309577912:64,853,975G/A—uncertain significance
rs253948242912:64,853,982T/G—pathogenic
rs20205666112:64,853,989T/C—likely benign
rs78087993612:64,853,990A/G—uncertain significance
rs213605662812:64,853,991T/G—uncertain significance
rs74806184612:64,854,006A/G—conflicting classifications of pathogenicity
rs75601182512:64,854,009T/G—uncertain significance
rs1153842012:64,854,016C/T—likely benign
rs213605665212:64,854,023C/G—uncertain significance
rs204053197112:64,854,027T/G—uncertain significance
rs101093001512:64,854,030A/C—uncertain significance
rs253948257112:64,854,034T/C—likely benign
rs213605667412:64,854,044G/A—uncertain significance
rs104299183312:64,854,053G/A—uncertain significance
rs54501154612:64,854,056T/C—likely benign
rs76117529312:64,854,079T/C—likely benign
rs14372798812:64,854,082T/C—benign
rs77703701712:64,854,085C/G—likely benign
rs75125321412:64,854,098A/G—uncertain significance
rs213605675012:64,854,113A/C—uncertain significance
rs54843762412:64,854,128A/G—likely benign
rs1117540312:64,857,885G/A—likely benign
rs77704407412:64,858,115C/T—uncertain significance
rs159235635712:64,858,116A/G—likely benign
rs253948878112:64,858,120A/G—uncertain significance
rs131177668012:64,858,121C/G—uncertain significance
rs253948885912:64,858,138A/G—uncertain significance
rs204058085912:64,858,155A/C—likely benign
rs253948895112:64,858,171A/G—uncertain significance
rs253948897012:64,858,174G/A—uncertain significance
rs156581350712:64,858,175T/A—uncertain significance
rs76713405012:64,858,177T/A—uncertain significance
rs37195505912:64,858,186C/G—uncertain significance
rs129797747612:64,858,197C/T—likely benign
rs136666878912:64,858,199A/G—uncertain significance
rs159235644012:64,858,215T/C—likely benign
rs75720378312:64,858,234C/T—pathogenic
rs13972661412:64,858,235G/A—uncertain significance
rs20087980812:64,858,237G/A—likely pathogenic
rs253948909512:64,858,238A/T—uncertain significance
rs53040540212:64,858,247T/C—likely benign
rs213606112412:64,858,248G/A—uncertain significance
rs213606113312:64,858,250T/C—uncertain significance
rs20038246712:64,858,256A/G—benign
rs37355180012:64,858,260A/G—likely benign
rs7565714112:64,858,316A/T—likely benign
rs11684161812:64,860,437C/G—likely benign
rs18879180612:64,860,447A/G—likely benign
rs7769898512:64,860,637G/A—benign
rs14446285012:64,860,700A/G—likely benign
rs106479717012:64,860,701C/Tstop gainedpathogenic
rs133769847512:64,860,702G/A—uncertain significance
rs74984734912:64,860,703A/C—likely benign
rs144563415312:64,860,707A/G—uncertain significance
rs159235809212:64,860,722C/T—uncertain significance
rs126468708112:64,860,723G/A—uncertain significance
rs204061169012:64,860,724T/C—likely benign
rs253949312612:64,860,726A/G—uncertain significance
rs144033926712:64,860,744T/C—uncertain significance
rs102724900212:64,860,749C/T—conflicting classifications of pathogenicity
rs76135900012:64,860,750G/A—uncertain significance
rs77626372712:64,860,752G/A—uncertain significance
rs4129202112:64,860,759G/C—uncertain significance
rs75143929012:64,860,760G/A—likely benign
rs37280863012:64,860,761G/A—likely benign
rs141300240212:64,860,762A/G—uncertain significance
rs76790234012:64,860,769A/G—likely benign
rs5582417212:64,860,774C/Tmissense variantpathogenic
rs20201177112:64,860,776G/C—uncertain significance
rs155520294712:64,860,798G/C—risk factor
rs213606360612:64,860,833G/A—uncertain significance
rs7331386912:64,860,841G/A—likely benign
rs213606362912:64,860,849C/T—uncertain significance
rs253949340612:64,860,855A/G—uncertain significance
rs213606363112:64,860,857T/C—uncertain significance
rs253950316312:64,867,992T/C—likely benign
rs74773886612:64,868,007T/G—uncertain significance
rs159236260912:64,868,017A/G—uncertain significance

Showing 100 of 372 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.